Latest Articles

  • A middle-aged man with progressive neurologic deficits and bilateral leg lesions
    Marc Williams, MD, Brendan J. Kelley, MD, Stephen Samples, MD and Maryann Mays, MD
    Cleveland Clinic Journal of Medicine March 2006, 73 (3) 269-272;

    His speech is severely impaired and he cannot swallow liquids or solids. The leg lesions have been present for several years and are painless. What is the likely diagnosis?

  • Preoperative pulmonary evaluation
    Amir K. Jaffer, MD, Franklin A. Michota, MD and Gerald W. Smetana, MD
    Cleveland Clinic Journal of Medicine March 2006, 73 (3 suppl 1) S36-S41;
  • Diagnosing and managing posttraumatic stress disorder
    Kumar Budur, MD, Tatiana Falcone, MD and Kathleen Franco, MD
    Cleveland Clinic Journal of Medicine February 2006, 73 (2) 121-129;

    PTSD not only affects soldiers, it also occurs in civilians exposed to severe trauma or serious illness. Manifestations commonly include nonspecific physical symptoms, and patients often present to their primary care physician.

  • A hypertensive emergency in an obese young woman
    Raja Shekhar R. Sappati Biyyani, MD, Loren M. Kirchner, MD, MS, Anil C. Singh, MD, MPH and Prabhacharan Gill, MD
    Cleveland Clinic Journal of Medicine February 2006, 73 (2) 110-120;

    She has headache, new-onset seizures, edema, and proteinuria; her blood pressure is 235/114 mm Hg and she weighs 256 lb. What is the diagnosis?

  • Multiple sclerosis: Treating symptoms, and other general medical issues
    Myla D. Goldman, MD, Jeffrey A. Cohen, MD, Robert J. Fox, MD and Francois A. Bethoux, MD
    Cleveland Clinic Journal of Medicine February 2006, 73 (2) 177-186;

    Disease-modifying therapies have been a big advance in multiple sclerosis, but many patients still experience a variety of symptoms that reduce quality of life. We have to treat the whole patient.

  • Improved outcomes in nephrotic syndrome
    Gerald B. Appel, MD
    Cleveland Clinic Journal of Medicine February 2006, 73 (2) 161-167;

    Nephrotic syndrome now has a dramatically different prognosis than it did 10 years ago. We can now effectively treat all types and achieve remission in many cases.

  • <em>Clostridium difficile</em>-associated disease: New challenges from an established pathogen
    Clostridium difficile-associated disease: New challenges from an established pathogen
    Rebecca H. Sunenshine, MD and L. Clifford McDonald, MD
    Cleveland Clinic Journal of Medicine February 2006, 73 (2) 187-197;

    Clostridium difficile-associated disease (CDAD) is increasing in incidence and severity and may be becoming more difficult to treat. A new strain is causing many outbreaks.

  • Evaluating and managing hypogammaglobulinemia
    Mark E. Rose, MD and David M. Lang, MD
    Cleveland Clinic Journal of Medicine February 2006, 73 (2) 133-144;

    Patients with frequent and recurrent respiratory infections should be tested for immune system abnormalities. This article describes common primary and secondary forms of hypogammaglobulinemia and how to evaluate and manage them.

  • Natriuretic peptide testing: A window into the diagnosis and prognosis of heart failure
    James L. Januzzi, MD
    Cleveland Clinic Journal of Medicine February 2006, 73 (2) 149-157;

    BNP assays are now widely used to evaluate suspected heart failure, but they should not be the only criterion.

  • A great masquerader learns a new trick
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine February 2006, 73 (2) 105;

    Different generations of physicians have proposed various contenders for the title of “great masquerader.” I firmly believe that Clostridium difficile infection deserves a shot at the title.

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