Latest Articles

  • Updates in the medical management of Parkinson disease
    Hubert H. Fernandez, MD
    Cleveland Clinic Journal of Medicine January 2012, 79 (1) 28-35; DOI: https://doi.org/10.3949/ccjm.78gr.11005

    Most, if not all, currently available drugs for Parkinson disease address dopaminergic loss and relieve symptoms. However, their adverse effects can be limiting and they do not address disease progression. Moreover, nonmotor features of Parkinson disease such as depression, dementia, and psychosis are now recognized as important and disabling. A cure remains elusive. However, promising interventions and agents are emerging. As an example, people who exercise regularly are less likely to develop Parkinson disease, and if they develop it, they tend to have slower progression.

  • Addressing disparities in health care
    Charles S. Modlin, MD, MBA
    Cleveland Clinic Journal of Medicine January 2012, 79 (1) 44-45; DOI: https://doi.org/10.3949/ccjm.79a.11167
  • Is niacin ineffective? Or did AIM-HIGH miss its target?
    Stephen J. Nicholls, MBBS, PhD
    Cleveland Clinic Journal of Medicine January 2012, 79 (1) 38-43; DOI: https://doi.org/10.3949/ccjm.79a.11166

    The AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes) found, in an interim analysis, no cardiovascular benefit from taking extended-release niacin (Niaspan). In fact, there was a trend toward a greater risk of ischemic stroke, which did not reach statistical significance. But questions remain about this complex trial, which included intensive statin therapy in the active-treatment group and the control group.

  • Bugs, pundits, evolution, and the New Year
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine January 2012, 79 (1) 10; DOI: https://doi.org/10.3949/ccjm.79b.12001
  • Overcoming barriers to hypertension control in African Americans
    Taiye Odedosu, MD, Antoinette Schoenthaler, EdD, Dorice L. Vieira, MLS, MPH, MA, Charles Agyemang, PhD and Gbenga Ogedegbe, MD
    Cleveland Clinic Journal of Medicine January 2012, 79 (1) 46-56; DOI: https://doi.org/10.3949/ccjm.79a.11068
  • Diffuse reticulonodular infiltrates
    Maria Giselle S. Velez, MD, FACP and Vicente Jose M. Velez, MD, FACP
    Cleveland Clinic Journal of Medicine January 2012, 79 (1) 16-17; DOI: https://doi.org/10.3949/ccjm.78a.11009
  • Managing community-acquired pneumonia during flu season
    Sarah Haessler, MD and Jennifer J. Schimmel, MD
    Cleveland Clinic Journal of Medicine January 2012, 79 (1) 67-78; DOI: https://doi.org/10.3949/ccjm.79a.11108
  • Skin and soft-tissue infections: Classifying and treating a spectrum
    Sabitha Rajan, MD, MSc, FHM
    Cleveland Clinic Journal of Medicine January 2012, 79 (1) 57-66; DOI: https://doi.org/10.3949/ccjm.79a.11044
  • A 25-year-old man with very high alkaline phosphatase
    Jamak Modaresi Esfeh, MD, Ibrahim A. Hanouneh, MD and Nizar N. Zein, MD
    Cleveland Clinic Journal of Medicine December 2011, 78 (12) 793-800; DOI: https://doi.org/10.3949/ccjm.78a.10166

    He has generalized malaise, a palpably enlarged liver, and an alkaline phosphatase level of 1,307 U/L. What is the cause?

  • Correction
    Cleveland Clinic Journal of Medicine December 2011, 78 (12) 787; DOI: https://doi.org/10.3949/ccjm.78c.12005

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