Latest Articles
- Parkinson’s disease: where do westand?
Although a cure has not been found, certain drugs can relieve symptoms and may actually slow disease progression.
- The fifth report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure: insights and highlights from the chairman
Highlights include the new classification schema and recommendations on the use of labetalol.
- Parathyroid carcinoma: 50-year experience at The Cleveland Clinic Foundation
BACKGROUND Parathyroid carcinoma is rare, with a reported prevalence of 0.6% to 4.0% in patients presumed to have primary hyperparathyroidism. This study examines the long-term results of surgical therapy and combination chemotherapy.
PATIENTS From 1938 to 1988, 1260 operations for primary hyperparathyroidism were performed; only six patients (0.47%) were subsequently found to have parathyroid carcinoma. A seventh patient was referred to our institution after the diagnosis of parathyroid carcinoma had been made.
RESULTS All patients had excessive hypercalcemia (serum calcium concentration > 12.0 mg/dL) with a range of 12.3 to 18.3 mg/dL. Locally recurrent tumors causing recurrent hypercalcemia were managed by repeated neck exploration and tumor resection. Six of the seven patients (85%) survived 5 years, while four patients (57%) survived 10 years.
CONCLUSIONS Diagnosis of parathyroid carcinoma rests upon postoperative surveillance of patients who have undergone previous neck exploration and resection of apparently benign adenomas. Long-term survival is possible with repeated resection of locally recurrent tumors.
- Assessing hypertension management: the role of 24-hour blood pressure monitoring
BACKGROUND The first fully automatic portable invasive blood pressure recorder was developed 30 years ago. Today, portable noninvasive ambulatory blood pressure devices are capable of measuring blood pressure intermittently for periods of 24 to 48 hours.
OBJECTIVE To discuss the utility of automatic ambulatory blood pressure recording in assessing antihypertensive therapy.
SUMMARY Ambulatory blood pressure monitoring is helpful in assessing the pharmacodynamics and the clinical efficacy of an-tihypertensive drugs. It is superior to office blood pressure measurement in predicting hypertensive end-organ disease. In clinical trials, ambulatory blood pressure monitoring permits a more varied population to enter a study, the number of subjects required is often reduced, and a placebo control group may be unnecessary.
CONCLUSIONS The various methods of analyzing ambulatory blood pressure data should be used in a complementary fashion to evaluate antihypertensive drug therapy. We believe that this technique will soon become much more commonly used for hypertension management.
- Irritable bowel syndrome: new perspectives on management
Long classified as psychosomatic, irritable bowel syndrome is now considered a motor disorder in which a number of factors are at play.