Latest Articles
- How should one investigate a chronic cough?
First, take the history, perform a physical examination, and order a chest radiograph.
- Goal-directed antihypertensive therapy: Lower may not always be better
At least 16 trials have been done in which patients were randomly assigned different blood pressure goals. Surprisingly, they did not show that a lower target offered significant clinical benefit, and they suggest the potential for harm.
- Hypertension: Don’t worry about the J curve—treat the patient
Concerns over being too aggressive remain theoretical. A far greater problem is that we are still not successfully treating hypertension to even a conservative target.
- MAO inhibitors (December 2010)
A reader comments on the use of monoamine oxidase inhibitors to treat depression (December 2010) and on the treatment of gout in patients with chronic kidney disease (December 2010).
- The Journal at 80 years: ‘Same as it ever was’—sort of
In the 1980s, the musical group Talking Heads sang, “You may ask yourself, How did I get here?”—an appropriate question as we begin our 80th year.
Proton pump inhibitor side effects and drug interactions: Much ado about nothing?In general, the safety of this class of drugs has been excellent. However, epidemiologic studies have indicated risks that are biologically plausible.
- Premenopausal osteoporosis, an overlooked consequence of anorexia nervosa
Particularly at risk are female athletes. The etiology is complex; the key treatment is to restore body weight.
- A 31-year-old man with abdominal pain and a rectal nodule
He has had pain and diarrhea for 4 days. What is the likely cause?