Latest Articles

  • Goal-directed antihypertensive therapy: Lower may not always be better
    Edward J. Filippone, MD, Andrew Foy, MD and Eric Newman, DO
    Cleveland Clinic Journal of Medicine February 2011, 78 (2) 123-133; DOI: https://doi.org/10.3949/ccjm.78a.10101

    At least 16 trials have been done in which patients were randomly assigned different blood pressure goals. Surprisingly, they did not show that a lower target offered significant clinical benefit, and they suggest the potential for harm.

  • Hypertension: Don’t worry about the J curve—treat the patient
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine February 2011, 78 (2) 74; DOI: https://doi.org/10.3949/ccjm.78b.11002

    Concerns over being too aggressive remain theoretical. A far greater problem is that we are still not successfully treating hypertension to even a conservative target.

  • MAO inhibitors (December 2010)
    David Keller, MD
    Cleveland Clinic Journal of Medicine February 2011, 78 (2) 81; DOI: https://doi.org/10.3949/ccjm.78c.02003

    A reader comments on the use of monoamine oxidase inhibitors to treat depression (December 2010) and on the treatment of gout in patients with chronic kidney disease (December 2010).

  • In reply: Gout and chronic kidney disease (December 2010)
    Brian F. Mandell, MD, PhD and Hossam El-Zawawy, MD, MS
    Cleveland Clinic Journal of Medicine February 2011, 78 (2) 81-82; DOI: https://doi.org/10.3949/ccjm.78c.02002
  • Airway pressure release ventilation: An alternative mode of mechanical ventilation in acute respiratory distress syndrome
    Ariel Modrykamien, MD, Robert L. Chatburn, MHHS, RRT-NPS and Rendell W. Ashton, MD
    Cleveland Clinic Journal of Medicine February 2011, 78 (2) 101-110; DOI: https://doi.org/10.3949/ccjm.78a.10032

    This mode may be useful in situations in which the lungs need to be recruited (reinflated) and held open.

  • In reply: MAO inhibitors (December 2010)
    Olga Kostenko, MD, Molly Wimbiscus, MD and Donald Malone, MD
    Cleveland Clinic Journal of Medicine February 2011, 78 (2) 81; DOI: https://doi.org/10.3949/ccjm.78c.02004
  • A 31-year-old man with abdominal pain and a rectal nodule
    Jacqueline Chu, BA and J. Harry Isaacson, MD
    Cleveland Clinic Journal of Medicine January 2011, 78 (1) 59-62; DOI: https://doi.org/10.3949/ccjm.77a.10084

    He has had pain and diarrhea for 4 days. What is the likely cause?

  • Do patients with prosthetic joints require dental antimicrobial prophylaxis?
    Eric Omar Gomez, MD, Douglas R. Osmon, MD, MPH and Elie F. Berbari, MD
    Cleveland Clinic Journal of Medicine January 2011, 78 (1) 36-38; DOI: https://doi.org/10.3949/ccjm.77a.10062

    The authors contend that the available evidence does not support routine prophylaxis before dental procedures.

  • Series Introduction
    Timothy Gilligan, MD
    Cleveland Clinic Journal of Medicine January 2011, 78 (1) 24; DOI: https://doi.org/10.3949/ccjm.78a.10179

    To keep our readers up to date on progress in palliative medicine, we are presenting a series of articles on the topic.

  • Managing bloodstream infections in patients who have short-term central venous catheters
    Naomi P. O’grady, MD and Daniel S. Chertow, MD
    Cleveland Clinic Journal of Medicine January 2011, 78 (1) 10-17; DOI: https://doi.org/10.3949/ccjm.77a.10015

    Should a potentially infected catheter be removed? Which empiric antibiotic therapy should be started? And how should therapy be tailored to the specific pathogen?

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