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Selected Papers in Dermatology

Porphyria cutanea tarda and bullous dermatoses associated with chronic renal failure: a review

Cary I. Goldsman and James S. Taylor, M.D.
Cleveland Clinic Journal of Medicine June 1983, 50 (2) 151-161;
Cary I. Goldsman
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James S. Taylor
Department of Dermatology, The Cleveland Clinic Foundation.
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ABSTRACT

In porphyria cutanea tarda, clinical expression may require the concordance of an inherited deficiency of the hepatic or erythrocyte enzyme uroporphyrinogen decarboxylase and an environmental precipitant, usually alcohol, iron, or estrogens. Recently, PCT and similar vesiculobullous disorders have been reported with increasing frequency in patients with impaired renal function. Many were on hemodialysis and others had ingested the photosensitizing drugs nalidixic acid and furosemide. Aluminum hydroxide and plasticizers from the dialysis tubing have also been implicated. Since abnormalities of porphyrin biochemistry were not found in all cases, more detailed porphyrin studies will be required. Plasma exchange was successful in treating one recent case of PCT in a patient on hemodialysis.

Index terms
  • Bullous dermatoses
  • Kidneys
  • failure
  • Porphyria cutanea tarda
  • Received February 1983.
  • Accepted March 1983.
  • Copyright © 1983 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 50 (2)
Cleveland Clinic Journal of Medicine
Vol. 50, Issue 2
20 Jun 1983
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Porphyria cutanea tarda and bullous dermatoses associated with chronic renal failure: a review
Cary I. Goldsman, James S. Taylor
Cleveland Clinic Journal of Medicine Jun 1983, 50 (2) 151-161;

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Porphyria cutanea tarda and bullous dermatoses associated with chronic renal failure: a review
Cary I. Goldsman, James S. Taylor
Cleveland Clinic Journal of Medicine Jun 1983, 50 (2) 151-161;
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Keywords

  • Bullous dermatoses
  • Kidneys
  • failure
  • Porphyria cutanea tarda

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