Skip to main content

Main menu

  • Home
  • Content
    • Current Issue
    • Ahead of Print
    • Past Issues
    • Supplements
    • Article Type
  • Specialty
    • Articles by Specialty
  • CME/MOC
    • Articles
    • Calendar
  • Info For
    • Manuscript Submission
    • Authors & Reviewers
    • Subscriptions
    • About CCJM
    • Contact Us
    • Media Kit
  • Conversations with Leaders
  • Conference Coverage
    • Kidney Week 2024
    • CHEST 2024
    • ACR Convergence 2023
    • Kidney Week 2023
    • ObesityWeek 2023
    • IDWeek 2023
    • CHEST 2023
    • MDS 2023
    • IAS 2023
    • ACP 2023
    • AAN 2023
    • ACC / WCC 2023
    • AAAAI Meeting 2023
    • ACR Convergence 2022
    • Kidney Week 2022
    • AIDS 2022
  • Other Publications
    • www.clevelandclinic.org

User menu

  • Register
  • Log in

Search

  • Advanced search
Cleveland Clinic Journal of Medicine
  • Other Publications
    • www.clevelandclinic.org
  • Register
  • Log in
Cleveland Clinic Journal of Medicine

Advanced Search

  • Home
  • Content
    • Current Issue
    • Ahead of Print
    • Past Issues
    • Supplements
    • Article Type
  • Specialty
    • Articles by Specialty
  • CME/MOC
    • Articles
    • Calendar
  • Info For
    • Manuscript Submission
    • Authors & Reviewers
    • Subscriptions
    • About CCJM
    • Contact Us
    • Media Kit
  • Conversations with Leaders
  • Conference Coverage
    • Kidney Week 2024
    • CHEST 2024
    • ACR Convergence 2023
    • Kidney Week 2023
    • ObesityWeek 2023
    • IDWeek 2023
    • CHEST 2023
    • MDS 2023
    • IAS 2023
    • ACP 2023
    • AAN 2023
    • ACC / WCC 2023
    • AAAAI Meeting 2023
    • ACR Convergence 2022
    • Kidney Week 2022
    • AIDS 2022
III. Articles and Features of General Interest

A new look at the old mosaic

Jacques Genest, C. C., M.D.
Cleveland Clinic Journal of Medicine June 1984, 51 (2) 449-461;
Jacques Genest
2Scientific Director, Clinical Research Institute of Montreal, and Director, Multidisciplinary Research Group on Hypertension of the Medical Research Council of Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

ABSTRACT

The author pays tribute to Dr. Irvine H. Page, whose life was a "mosaic" of key scientific contributions in the field of hypertension and of professional and societal involvement. Important and recent contributions are brought together to confirm the hypothesis, as expressed by Dr. Page in 1937, that the secretions of some endocrine glands, in particular, the adrenal cortex, keep the vascular system in a hyper-reactive state. Evidence is presented to demonstrate that increased peripheral resistance and chronic hypertension are neither due to an increase in cardiac output or plasma or extracellular fluid volume nor arteriosclerotic lesions, but are primarily related to increased arterial sensitivity and responsiveness to pressor agents, such as norepinephrine and angiotensin II. The sodium balance, which is mainly determined by the production of aldosterone in the adrenal cortex, is fundamentally involved in the increased peripheral resistance of hypertension. Since hypertension is the result of disequilibrium between the sympathetic nervous system activity and the state of sensitivity and reactivity of the contractile proteins in the arterial walls, models are proposed based on increased sympathetic nervous system activity, increased activity of the renin-angiotensin system, and a disturbance in aldosterone regulation and sodium transport across cell membranes and which are associated with the increased sensitivity and reactivity of the arterioles.

Index terms
  • Hypertension
  • Irvine H. Page Lecture
  • Copyright © 1984 The Cleveland Clinic Foundation. All Rights Reserved.
PreviousNext
Back to top

In this issue

Cleveland Clinic Journal of Medicine: 51 (2)
Cleveland Clinic Journal of Medicine
Vol. 51, Issue 2
20 Jun 1984
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Cleveland Clinic Journal of Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
A new look at the old mosaic
(Your Name) has sent you a message from Cleveland Clinic Journal of Medicine
(Your Name) thought you would like to see the Cleveland Clinic Journal of Medicine web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
A new look at the old mosaic
Jacques Genest
Cleveland Clinic Journal of Medicine Jun 1984, 51 (2) 449-461;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
A new look at the old mosaic
Jacques Genest
Cleveland Clinic Journal of Medicine Jun 1984, 51 (2) 449-461;
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Linkedin Share Button

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Congenital anomalies of the lung in the adult
  • Chemical pneumonia in workers extracting beryllium oxide
  • Juvenile aponeurotic fibroma: a case report of a rare tumor
Show more III. Articles and Features of General Interest

Similar Articles

Keywords

  • Hypertension
  • Irvine H. Page Lecture

Navigate

  • Current Issue
  • Past Issues
  • Supplements
  • Article Type
  • Specialty
  • CME/MOC Articles
  • CME/MOC Calendar
  • Media Kit

Authors & Reviewers

  • Manuscript Submission
  • Authors & Reviewers
  • Subscriptions
  • About CCJM
  • Contact Us
  • Cleveland Clinic Center for Continuing Education
  • Consult QD

Share your suggestions!

Copyright © 2025 The Cleveland Clinic Foundation. All rights reserved. The information provided is for educational purposes only. Use of this website is subject to the website terms of use and privacy policy. 

Powered by HighWire