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I. Rheumatic and Immunologic Disease: Selected Papers

The association of lupus anticoagulant and anti-DNA binding in patients with systemic lupus erythematosus

Ralph E. Bennett, M.D., Leonard H. Calabrese, D.O., Fred V. Lucas, M.D. and John D. Clough, M.D.
Cleveland Clinic Journal of Medicine June 1985, 52 (2) 115-118;
Ralph E. Bennett
Department of Rheumatic and Immunologic Disease, The Cleveland Clinic Foundation.
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Leonard H. Calabrese
Department of Rheumatic and Immunologic Disease, The Cleveland Clinic Foundation.
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Fred V. Lucas
Department of Laboratory Hematology, The Cleveland Clinic Foundation.
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John D. Clough
Department of Rheumatic and Immunologic Disease, The Cleveland Clinic Foundation.
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ABSTRACT

A study was undertaken to ascertain the association of lupus anticoagulant and anti-DNA binding in patients with systemic lupus erythematosus (SLE). The sera of 67 patients who had positive antinuclear factor were studied to determine whether antibodies to DNA are associated with lupus anticoagulant and if so whether anticoagulant and anti-DNA properties reside on the same immunoglobulin. Binding to native DNA was determined by a modified Farr’s assay, and lupus anticoagulant activity was determined by modified kaolin-activated partial thromboplastin time. Of 67 patients, 14 had positive findings for circulating anticoagulant, 37 had antibodies to DNA, and 30 did not. All 14 patients who had circulating anticoagulants had anti-DNA, and conversely, no patient without DNA binding had a lupus anticoagulant. Furthermore, absorption of the test sera with the phospholipid phosphatidyl serine was capable of removing DNA binding in every sera demonstrating lupus anticoagulant and anti-DNA activity. Although it is not clear whether anti-DNA binding and lupus anticoagulant activity coexist in the same immunoglobulin in SLE, lupus anticoagulant and anti-DNA showed a strong positive association in patients with SLE.

Index terms
  • Blood coagulation factors
  • DNA
  • immunology
  • Lupus erythematosus
  • systemic
  • Received December 1984.
  • Accepted March 1985.
  • Copyright © 1985 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 52 (2)
Cleveland Clinic Journal of Medicine
Vol. 52, Issue 2
20 Jun 1985
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The association of lupus anticoagulant and anti-DNA binding in patients with systemic lupus erythematosus
Ralph E. Bennett, Leonard H. Calabrese, Fred V. Lucas, John D. Clough
Cleveland Clinic Journal of Medicine Jun 1985, 52 (2) 115-118;

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The association of lupus anticoagulant and anti-DNA binding in patients with systemic lupus erythematosus
Ralph E. Bennett, Leonard H. Calabrese, Fred V. Lucas, John D. Clough
Cleveland Clinic Journal of Medicine Jun 1985, 52 (2) 115-118;
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Keywords

  • Blood coagulation factors
  • DNA
  • immunology
  • Lupus erythematosus
  • systemic

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