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Case Report

Fatal ethylene glycol intoxication

Report of a case and review of the literature

Michael R. Verrilli, M.S., D.O., Cynthia L. Deyling, M.D., C. E. Pippenger, Ph.D., Frederick Van Lente, Ph.D., Donald G. Vidt, M.D. and Edward D. Sivak, M.D.
Cleveland Clinic Journal of Medicine July 1987, 54 (4) 289-295;
Michael R. Verrilli
Department of Internal Medicine, The Cleveland Clinic Foundation
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Cynthia L. Deyling
Department of Internal Medicine, The Cleveland Clinic Foundation
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C. E. Pippenger
Department of Biochemistry (Head, Section of Applied Clinical Pharmacology), The Cleveland Clinic Foundation
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Frederick Van Lente
Department of Biochemistry (Head, Section of Automated Chemistry), The Cleveland Clinic Foundation
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Donald G. Vidt
Department of Hypertension and Nephrology (Head, Clinical Section), The Cleveland Clinic Foundation
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Edward D. Sivak
Department of Pulmonary Disease, The Cleveland Clinic Foundation
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ABSTRACT

The authors describe a 27-year-old man with signs of acute ethylene glycol intoxication, including coma, absent pupillary reflexes, hypotonia, and hyporeflexia, plus laboratory evidence of a high-anion-gap metabolic acidosis, an osmolal gap, calcium oxalate monohydrate crystalluria, and elevated serum ethylene glycol levels. He failed to respond to sodium bicarbonate and ethanol therapy and died immediately before hemodialysis. The diagnosis, clinical presentation, pathophysiology, and treatment of acute ethylene glycol intoxication are reviewed.

Index terms
  • Ethylene glycol
  • Poisoning
  • Received June 1986.
  • Accepted September 1986.
  • Copyright © 1987 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 54 (4)
Cleveland Clinic Journal of Medicine
Vol. 54, Issue 4
1 Jul 1987
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Fatal ethylene glycol intoxication
Michael R. Verrilli, Cynthia L. Deyling, C. E. Pippenger, Frederick Van Lente, Donald G. Vidt, Edward D. Sivak
Cleveland Clinic Journal of Medicine Jul 1987, 54 (4) 289-295;

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Fatal ethylene glycol intoxication
Michael R. Verrilli, Cynthia L. Deyling, C. E. Pippenger, Frederick Van Lente, Donald G. Vidt, Edward D. Sivak
Cleveland Clinic Journal of Medicine Jul 1987, 54 (4) 289-295;
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Keywords

  • Ethylene glycol
  • Poisoning

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