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Dermatology Feature

Cutaneous Wegener’s granulomatosis

Report of a case and review of the literature

Molly J. Norris, MD, Wilma F. Bergfeld, MD, FACP and William S. Wilke, MD
Cleveland Clinic Journal of Medicine March 1988, 55 (2) 181-184;
Kenneth J. Tomecki
Department of Dermatology, The Cleveland Clinic Foundation
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Molly J. Norris
Department of Dermatology, The Cleveland Clinic Foundation
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Wilma F. Bergfeld
Department of Dermatology, The Cleveland Clinic Foundation
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William S. Wilke
Department of Rheumatology, The Cleveland Clinic Foundation
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ABSTRACT

A 32-year-old man with documented Wegener’s granulomatosis had papules and pustules on his elbows, hands, and feet and petechiae on his palms and soles. Skin biopsy showed chronic vasculitis and epidermal necrosis. The patient’s condition improved markedly after chemotherapy with nitrogen mustard, prednisone, and cyclophosphamide. This case illustrates characteristic clinical and histopathologic findings of cutaneous Wegener’s granulomatosis based on a current literature review. Although no one skin change is pathognomonic of Wegener’s granulomatosis, certain cutaneous findings are suggestive of the disease. Clinicians should be aware of these skin changes to aid early diagnosis and treatment of a rapidly fatal but potentially treatable disease.

Index term
  • Wegener’s granulomatosis
  • Received June 1987.
  • Accepted July 1987.
  • Copyright © 1988 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 55 (2)
Cleveland Clinic Journal of Medicine
Vol. 55, Issue 2
1 Mar 1988
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Cutaneous Wegener’s granulomatosis
Molly J. Norris, Wilma F. Bergfeld, William S. Wilke
Cleveland Clinic Journal of Medicine Mar 1988, 55 (2) 181-184;

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Cutaneous Wegener’s granulomatosis
Molly J. Norris, Wilma F. Bergfeld, William S. Wilke
Cleveland Clinic Journal of Medicine Mar 1988, 55 (2) 181-184;
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