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Pathology Feature

In vitro comparison of activity of Cefixime with activities of other orally administered antimicrobial agents

Cynthia C. Knapp, MS and John A. Washington, MD
Cleveland Clinic Journal of Medicine September 1988, 55 (5) 477-482;
William R. Hart
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Cynthia C. Knapp
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John A. Washington
Department of Microbiology, The Cleveland Clinic Foundation
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ABSTRACT

Cefixime, cefuroxime, cephalexin, cefaclor, penicillin, ampicillin, amoxicillin alone and combined with clavulanate, erythromycin, and trimethoprim/sulfamethoxazole were tested in vitro against nearly 1,100 clinical isolates of bacteria. Minimal inhibitory concentrations (MICs) of > 32 μg/mL were observed for all cephalosporins against > 90% (MIC90) of isolates of Citrobacter freundii, Enterobacter aerogenes, Enterobacter cloacae, Morganella morganii, A cinetobacter anitratus, and Pseudomonas sp. An MIC90 of < 0.25 μg of Cefixime per mL was observed with nonenterococcal streptococci, Klebsiella sp, Proteus mirabilis, Proteus vulgaris, Providencia stuartii, Salmonella sp, and Shigella sp. The MIC90 values of cefuroxime and amoxicillin/clavulanate were, respectively, > 32 and 16 μg/mL for Klebsiella oxytoca, 4 and 32 μg/mL for Klebsiella pneumoniae, 2 and 1 μg/mL for P mirabilis, and > 32 μg/mL for P stuartii. The MIC90 values of Cefixime, cefuroxime, amoxicillin/clavulanate, and trimethoprim/sulfamethoxazole were, respectively, 0.12, 2,0.12, and ≤ 0.5 μg/mL for Branhamella catarrhalis and 0.25, 4,8, and 4 μg/mL for Haemophilus influenzae. Overall, trimethoprim/sulfamethoxazole was the most active compound, followed by Cefixime.

INDEX TERM
  • Antibiotics
  • Lactam
  • Received November 1987.
  • Accepted January 1988.
  • Copyright © 1988 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 55 (5)
Cleveland Clinic Journal of Medicine
Vol. 55, Issue 5
1 Sep 1988
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In vitro comparison of activity of Cefixime with activities of other orally administered antimicrobial agents
Cynthia C. Knapp, John A. Washington
Cleveland Clinic Journal of Medicine Sep 1988, 55 (5) 477-482;

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In vitro comparison of activity of Cefixime with activities of other orally administered antimicrobial agents
Cynthia C. Knapp, John A. Washington
Cleveland Clinic Journal of Medicine Sep 1988, 55 (5) 477-482;
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