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Contributions

α1-Antitrypsin deficiency and augmentation therapy in emphysema

James K. Stoller, MD
Cleveland Clinic Journal of Medicine October 1989, 56 (7) 683-689;
James K. Stoller
Section of Respiratory Therapy, Department of Pulmonary Disease, Cleveland Clinic Foundation, One Clinic Center, 9500 Euclid Avenue, Cleveland, Ohio 44195
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ABSTRACT

Since the first description of α1-antitrypsin deficiency as a cause of emphysema in 1963, major strides have been made in understanding the structure and function of this important antiprotease, its role in the defense against emphysema, and in new treatment strategies. In order to elucidate the pathogenesis of antitrypsin-associated emphysema and recent developments in therapy for this disease, this paper considers current understanding of the pathogenesis of emphysema, recent information regarding the structure and function of the molecule, and more recent developments in augmentation therapy. The author also discusses the national registry that has been organized for better understanding of the natural history of α1-antitrypsin deficiency in a relatively unselected population.

INDEX TERMS
  • Alpha 1-Antitrypsin
  • Emphysema
  • Received May 1989.
  • Accepted June 1989.
  • Copyright © 1989 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 56 (7)
Cleveland Clinic Journal of Medicine
Vol. 56, Issue 7
1 Oct 1989
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α1-Antitrypsin deficiency and augmentation therapy in emphysema
James K. Stoller
Cleveland Clinic Journal of Medicine Oct 1989, 56 (7) 683-689;

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α1-Antitrypsin deficiency and augmentation therapy in emphysema
James K. Stoller
Cleveland Clinic Journal of Medicine Oct 1989, 56 (7) 683-689;
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Keywords

  • ALPHA 1-ANTITRYPSIN
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