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Contributions

Atrial natriuretic factor and catecholamine levels during exercise in patients with and without coronary artery disease

Benjamin D. Robalino, MD, Richard W. Petrella, MD, Ernesto E. Salcedo, MD, Raymundo T. Go, MD and Emmanuel L. Bravo, MD
Cleveland Clinic Journal of Medicine November 1991, 58 (6) 493-499;
Benjamin D. Robalino
Department of Cardiology, The Cleveland Clinic Foundation.
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Richard W. Petrella
Department of Cardiology, The Cleveland Clinic Foundation.
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Ernesto E. Salcedo
Department of Cardiology, The Cleveland Clinic Foundation.
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Raymundo T. Go
Department of Nuclear Medicine, The Cleveland Clinic Foundation.
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Emmanuel L. Bravo
Department of Heart and Hypertension Research, The Cleveland Clinic Foundation.
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ABSTRACT

To investigate the effects of exercise-induced ischemia on the release of atrial natriuretic factor (ANF), we measured peripheral plasma ANF, epinephrine and norepinephrine in 18 male patients with and without coronary artery disease. The patients underwent tomographic thallium treadmill stress tests. After exercise, patients with coronary artery disease showed higher increments of plasma ANF than patients without coronary disease, but the increase of ANF was not related to exercise-induced ischemia, nor to changes in catecholamines, heart rate, or blood pressure. This suggests that ANF release is not associated with myocardial ischemia per se, but to other factors which are more pronounced in the presence of coronary disease, such as changes in intracardiac pressures associated with exercise. Further studies are needed to clarify the role of myocardial ischemia on ANF release.

INDEX TERMS
  • Natriuretic Peptides
  • Atrial
  • Catecholamines
  • Coronary Disease
  • Exercise Test
  • Copyright © 1991 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine
Vol. 58, Issue 6
1 Nov 1991
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Atrial natriuretic factor and catecholamine levels during exercise in patients with and without coronary artery disease
Benjamin D. Robalino, Richard W. Petrella, Ernesto E. Salcedo, Raymundo T. Go, Emmanuel L. Bravo
Cleveland Clinic Journal of Medicine Nov 1991, 58 (6) 493-499;

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Atrial natriuretic factor and catecholamine levels during exercise in patients with and without coronary artery disease
Benjamin D. Robalino, Richard W. Petrella, Ernesto E. Salcedo, Raymundo T. Go, Emmanuel L. Bravo
Cleveland Clinic Journal of Medicine Nov 1991, 58 (6) 493-499;
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Keywords

  • Natriuretic Peptides
  • Atrial
  • Catecholamines
  • Coronary Disease
  • Exercise Test

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