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Contributions

Flurbiprofen in the prophylaxis of migraine

Glen D. Solomon, MD and Robert S. Kunkel, MD
Cleveland Clinic Journal of Medicine January 1993, 60 (1) 43-48;
Glen D. Solomon
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Robert S. Kunkel
Headache Center, The Cleveland Clinic Foundation.
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ABSTRACT

Flurbiprofen, a nonsteroidal anti-inflammatory drug with effects on prostaglandin synthesis, platelet serotonin release, and beta-endorphin, was studied for efficacy in migraine prophylaxis. Twenty-three patients completed the 20-week, placebo-controlled, double-blind, crossover trial. Flurbiprofen, in a dose of 100 mg twice daily, and placebo were each given for 8 weeks, with a 2-week "washout" period between the treatment periods. Flurbiprofen significantly reduced migraine intensity (P < .05), total hours with migraine (P < .015), and the dosing frequency of relief medication (P < .015). Total hours with migraine decreased by 41%, and the use of relief medication decreased by 31%. The reduction in migraine frequency did not reach statistical significance (P < .10). Adverse effects were infrequent. Based on the overall improvement in migraine parameters, flurbiprofen can be recommended for use in migraine prophylaxis.

INDEX TERMS
  • Flurbiprofen
  • Migrain
  • Copyright © 1993 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 60 (1)
Cleveland Clinic Journal of Medicine
Vol. 60, Issue 1
1 Jan 1993
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Flurbiprofen in the prophylaxis of migraine
Glen D. Solomon, Robert S. Kunkel
Cleveland Clinic Journal of Medicine Jan 1993, 60 (1) 43-48;

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Flurbiprofen in the prophylaxis of migraine
Glen D. Solomon, Robert S. Kunkel
Cleveland Clinic Journal of Medicine Jan 1993, 60 (1) 43-48;
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