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Interpreting Key Trials

The Mustt Trial

Preventing sudden death in coronary cardiomyopathy: Implantable defibrillators lead the way

Stephen Pavia, MD and Bruce L. Wilkoff, MD
Cleveland Clinic Journal of Medicine February 2001, 68 (2) 113-129;
Stephen Pavia
Department of Cardiology, Cleveland Clinic
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Bruce L. Wilkoff
Department of Cardiology, Cleveland Clinic
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ABSTRACT

The Multicenter Unsustained Tachycardia Trial (MUSTT) demonstrated that electrophysiologic testing (EP)-guided therapy significantly reduces arrhythmic death and cardiac arrest in patients with coronary artery disease, a left ventricular ejection fraction of 40% or less, nonsustained ventricular tachycardia, and inducible ventricular arrhythmia on EP testing—but only if the therapy includes an implantable defibrillator. All patients who meet the MUSTT inclusion criteria should undergo an EP test and if positive, should undergo defibrillator implantation.

Footnotes

  • ↵* The author has received grant support from and is on the advisory boards of Guidant, Medtronic, and St. Jude.

  • Copyright © 2001 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 68 (2)
Cleveland Clinic Journal of Medicine
Vol. 68, Issue 2
1 Feb 2001
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The Mustt Trial
Stephen Pavia, Bruce L. Wilkoff
Cleveland Clinic Journal of Medicine Feb 2001, 68 (2) 113-129;

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The Mustt Trial
Stephen Pavia, Bruce L. Wilkoff
Cleveland Clinic Journal of Medicine Feb 2001, 68 (2) 113-129;
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