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Interpreting Key Trials

Interpreting the African American Heart Failure Trial(A-HEFT)

Isosorbide dinitrate-hydralazine improves outcomes in African Americans with heart failure

Monica Colvin-Adams, MD and Anne L. Taylor, MD
Cleveland Clinic Journal of Medicine March 2007, 74 (3) 227-234;
Monica Colvin-Adams
Assistant professor of Medicine/Cardiology; medical director, Cardiac Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN
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Anne L. Taylor
Professor of Medicine/Cardiology and associate dean for Faculty Affairs, University of Minnesota Medical School; codirector, University of Minnesota National Center of Excellence in Women’s Health; chair, Steering Committee, African-American Heart Failure Trial (A-HeFT)
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ABSTRACT

The African American Heart Failure Trial (A-HeFT) found that African American patients with advanced heart failure fared better if the fixed-dose combination of isosorbide dinitrate and hydralazine was added to their regimen, which for most of them already included an angiotensin-converting enzyme (ACE) inhibitor or angiotensin-receptor blocker (ARB), a beta-blocker, and a diuretic (N Engl J Med 2004; 351:2049–2057). This placebo-controlled trial was the first to evaluate a therapy in a specific racial group, and it points the way to a more individualized approach to heart failure therapy.

Footnotes

  • ↵* Dr. Taylor has indicated that she has received research support and consulting fees from the NitroMed corporation, which also sponsored the African-American Heart Failure Trial.

  • Copyright © 2007 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 74 (3)
Cleveland Clinic Journal of Medicine
Vol. 74, Issue 3
1 Mar 2007
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Interpreting the African American Heart Failure Trial(A-HEFT)
Monica Colvin-Adams, Anne L. Taylor
Cleveland Clinic Journal of Medicine Mar 2007, 74 (3) 227-234;

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Interpreting the African American Heart Failure Trial(A-HEFT)
Monica Colvin-Adams, Anne L. Taylor
Cleveland Clinic Journal of Medicine Mar 2007, 74 (3) 227-234;
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