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Session I: Pathways Involved in Neuromodulation of Risks in Coronary Artery Disease

Pioneer Award Address: Ignorance isn’t biased: Comments on receiving the Pioneer Award

David S. Goldstein, MD, PhD
Cleveland Clinic Journal of Medicine February 2009, 76 (4 suppl 2) S31-S36; DOI: https://doi.org/10.3949/ccjm.76.s2.07
David S. Goldstein
Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
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ABSTRACT

Researchers ordinarily work by deriving testable hypotheses from theories using a deductive process. Hypothesis testing is inherently biased, however, because of the practical requirements of finding and publishing positive results. In contrast, ignorance isn’t biased. The combination of relevant new technology, sufficient mastery of the topic to know what is not yet known, and access to patients with rare but informative disorders sets the stage for discoveries about disease mechanisms based on induction from observations. Patient-oriented research is a strength of heart-brain medicine. Patients are a unique scientific resource because they tell us the truth. We experience the joy and thrill of a “sparkle of insight” when we realize what they teach.

  • © 2009 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 76 (4 suppl 2)
Cleveland Clinic Journal of Medicine
Vol. 76, Issue 4 suppl 2
1 Feb 2009
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Pioneer Award Address: Ignorance isn’t biased: Comments on receiving the Pioneer Award
David S. Goldstein
Cleveland Clinic Journal of Medicine Feb 2009, 76 (4 suppl 2) S31-S36; DOI: 10.3949/ccjm.76.s2.07

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Pioneer Award Address: Ignorance isn’t biased: Comments on receiving the Pioneer Award
David S. Goldstein
Cleveland Clinic Journal of Medicine Feb 2009, 76 (4 suppl 2) S31-S36; DOI: 10.3949/ccjm.76.s2.07
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