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Interpreting Key Trials

Interpreting the Jupiter trial: Statins can prevent VTE, but more study is needed

Alejandro Perez, MD and John R. Bartholomew, MD
Cleveland Clinic Journal of Medicine March 2010, 77 (3) 191-194; DOI: https://doi.org/10.3949/ccjm.77a.09077
Alejandro Perez
Section of Vascular Medicine, Department of Cardiovascular Medicine, Cleveland Clinic
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John R. Bartholomew
Head, Section of Vascular Medicine; Professor of Medicine, Department of Cardiovascular Medicine; and Department of Hematologic Oncology and Blood Disorders, Cleveland Clinic
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ABSTRACT

Analysis of a secondary end point of the JUPITER trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) found that a statin reduced the risk of venous thromboembolism (VTE) in apparently healthy people with high levels of C-reactive protein and normal levels of low-density lipoprotein cholesterol (N Engl J Med 2009; 360:1851– 1861). Still, pending more study, statins should not be substituted for proven prophylaxis and anticoagulation, especially for patients with recurrent deep venous thrombosis, hospitalized patients, postoperative patients, and other patients prone to VTE.

  • © 2010 The Cleveland Clinic Foundation. All Rights Reserved.

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Cleveland Clinic Journal of Medicine: 77 (3)
Cleveland Clinic Journal of Medicine
Vol. 77, Issue 3
1 Mar 2010
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Interpreting the Jupiter trial: Statins can prevent VTE, but more study is needed
Alejandro Perez, John R. Bartholomew
Cleveland Clinic Journal of Medicine Mar 2010, 77 (3) 191-194; DOI: 10.3949/ccjm.77a.09077

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Interpreting the Jupiter trial: Statins can prevent VTE, but more study is needed
Alejandro Perez, John R. Bartholomew
Cleveland Clinic Journal of Medicine Mar 2010, 77 (3) 191-194; DOI: 10.3949/ccjm.77a.09077
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