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Diagnosis, ANCA testing, and disease activity

Clinical features and diagnosis of small-vessel vasculitis

Carol Langford, MD, MHS
Cleveland Clinic Journal of Medicine November 2012, 79 (11 suppl 3) S3-S7; DOI: https://doi.org/10.3949/ccjm.79.s3.01
Carol Langford
Director, Center for Vasculitis Care and Research, Department of Rheumatic and Immunologic Disease, Cleveland Clinic, Cleveland, OH
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ABSTRACT

Vasculitis is inflammation of the blood vessel. Granulomatosis with polyangiitis (GPA), microscopic polyangiitis, and eosinophilic GPA are three small-vessel vasculitic diseases that share certain features, but also have important differences. Distinguishing these entities may influence the diagnostic approach, treatment decisions, and outcomes. Circulating antineutrophil cytoplasmic antibodies (ANCA) characterize all three diseases, although their immunofluorescence patterns and target antigen specificities differ. While the presence of ANCA can suggest these diagnoses, the diseases are best viewed as separate entities, each defined by specific clinical and histologic characteristics.

  • © 2012 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 79 (11 suppl 3)
Cleveland Clinic Journal of Medicine
Vol. 79, Issue 11 suppl 3
1 Nov 2012
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Clinical features and diagnosis of small-vessel vasculitis
Carol Langford
Cleveland Clinic Journal of Medicine Nov 2012, 79 (11 suppl 3) S3-S7; DOI: 10.3949/ccjm.79.s3.01

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Clinical features and diagnosis of small-vessel vasculitis
Carol Langford
Cleveland Clinic Journal of Medicine Nov 2012, 79 (11 suppl 3) S3-S7; DOI: 10.3949/ccjm.79.s3.01
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