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Indication Medications Considerations Long-acting pain control Fentanyl patch
Methadone
Morphine extended-releaseCurrent and predicted pain
Prior pain medication use, familiarity, and tolerance
Future ability to take oral medicationsBreakthrough pain or dyspnea Morphine sulfate oral solution Can be used when patient loses ability to purposefully swallow Terminal fever or pain Acetaminophen Pills can be used orally or rectally
Low risk of diversionNausea and vomiting Ondansetron
PromethazineConsider if single medications can be used for multiple symptoms Pain, nausea, cancer-related swelling, or obstruction Dexamethasone Multimodal effect
Benefits usually maximized over 2 weeks
Use cautiously if hyperglycemia is a concernTerminal agitation, anxiety, seizures, and nausea Lorazepam
Olanzapine
HaloperidolUseful for spectrum of symptoms in terminal phase Constipation Bisacodyl
Polyethylene glycolBisacodyl oral pill can be used rectally when patient loses ability to swallow Secretions, death rattle Atropine 1% drops Coach family on repositioning