More articles from Review

  • Pharmacogenomic testing: Relevance in medical practice
    Pharmacogenomic testing: Relevance in medical practice
    Joseph P. Kitzmiller, MD, PhD, David K. Groen, MD, Mitch A. Phelps, PhD and Wolfgang Sadee, Dr rer nat
    Cleveland Clinic Journal of Medicine April 2011, 78 (4) 243-257; DOI: https://doi.org/10.3949/ccjm.78a.10145

    Knowing their patients’ genetic status, physicians could predict their response to certain drugs, such as clopidogrel (Plavix), warfarin (Coumadin), tamoxifen (Nolvadex), codeine, and psychotropic medications.

  • Giant cell arteritis: Suspect it, treat it promptly
    Alexandra Villa-Forte, MD, MPH
    Cleveland Clinic Journal of Medicine April 2011, 78 (4) 265-270; DOI: https://doi.org/10.3949/ccjm.78a.10131

    Giant cell arteritis is the most common form of vasculitis affecting older people. Physicians should be familiar with its variety of clinical presentations.

  • Can a bowel preparation exacerbate heart failure?
    Kalindi Parikh, MD and Howard Weitz, MD
    Cleveland Clinic Journal of Medicine March 2011, 78 (3) 157-160; DOI: https://doi.org/10.3949/ccjm.77a.10025

    A 73-year-old man with a history of heart failure develops shortness of breath after consuming about 1 L of a polyethylene glycol solution in preparation for colonoscopy the next day.

  • Interpreting the estimated glomerular filtration rate in primary care: Benefits and pitfalls
    Interpreting the estimated glomerular filtration rate in primary care: Benefits and pitfalls
    James Simon, MD, Milen Amde, MD and Emilio D. Poggio, MD
    Cleveland Clinic Journal of Medicine March 2011, 78 (3) 189-195; DOI: https://doi.org/10.3949/ccjm.78a.10057

    Many laboratories are now reporting the glomerular filtration rate automatically, and primary care providers are left trying to interpret the results.

  • Air travel and venous thromboembolism: Minimizing the risk
    Air travel and venous thromboembolism: Minimizing the risk
    John R. Bartholomew, MD, Jonathan L. Schaffer, MD, MBA and Georges F. McCormick, MD
    Cleveland Clinic Journal of Medicine February 2011, 78 (2) 111-120; DOI: https://doi.org/10.3949/ccjm.78a.10138

    Blood clots can occur during air travel, although the absolute risk is low. People with hypercoagulable conditions are at greater risk and may need prophylaxis.

  • Goal-directed antihypertensive therapy: Lower may not always be better
    Edward J. Filippone, MD, Andrew Foy, MD and Eric Newman, DO
    Cleveland Clinic Journal of Medicine February 2011, 78 (2) 123-133; DOI: https://doi.org/10.3949/ccjm.78a.10101

    At least 16 trials have been done in which patients were randomly assigned different blood pressure goals. Surprisingly, they did not show that a lower target offered significant clinical benefit, and they suggest the potential for harm.

  • Airway pressure release ventilation: An alternative mode of mechanical ventilation in acute respiratory distress syndrome
    Ariel Modrykamien, MD, Robert L. Chatburn, MHHS, RRT-NPS and Rendell W. Ashton, MD
    Cleveland Clinic Journal of Medicine February 2011, 78 (2) 101-110; DOI: https://doi.org/10.3949/ccjm.78a.10032

    This mode may be useful in situations in which the lungs need to be recruited (reinflated) and held open.

  • Proton pump inhibitor side effects and drug interactions: Much ado about nothing?
    Proton pump inhibitor side effects and drug interactions: Much ado about nothing?
    Ryan D. Madanick, MD
    Cleveland Clinic Journal of Medicine January 2011, 78 (1) 39-49; DOI: https://doi.org/10.3949/ccjm.77a.10087

    In general, the safety of this class of drugs has been excellent. However, epidemiologic studies have indicated risks that are biologically plausible.

  • Premenopausal osteoporosis, an overlooked consequence of anorexia nervosa
    Kathryn Teng, MD
    Cleveland Clinic Journal of Medicine January 2011, 78 (1) 50-58; DOI: https://doi.org/10.3949/ccjm.78a.10023

    Particularly at risk are female athletes. The etiology is complex; the key treatment is to restore body weight.

  • Managing bloodstream infections in patients who have short-term central venous catheters
    Naomi P. O’grady, MD and Daniel S. Chertow, MD
    Cleveland Clinic Journal of Medicine January 2011, 78 (1) 10-17; DOI: https://doi.org/10.3949/ccjm.77a.10015

    Should a potentially infected catheter be removed? Which empiric antibiotic therapy should be started? And how should therapy be tailored to the specific pathogen?

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