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COVID-19 Curbside Consults

Airway management considerations in patients with COVID-19

Praveen Chahar, MD, FCARCSI, Sidharth Dugar, MD and Donn Marciniak, MD
Cleveland Clinic Journal of Medicine May 2020, DOI: https://doi.org/10.3949/ccjm.87a.ccc033
Praveen Chahar
Department of General Anesthesiology, Anesthesiology Institute, Cleveland Clinic
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Sidharth Dugar
Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic
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Donn Marciniak
Department of Intensive Care and Resuscitation, Anesthesiology Institute, Cleveland Clinic
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ABSTRACT

Approximately 12% to 15% of hospitalized patients with COVID-19 infection require invasive ventilation via endotracheal intubation. The key to minimizing risk of disease transmission during this aerosol-generating procedure is careful preparation, which includes having necessary equipment and medications on hand as well as an experienced intubation team who can troubleshoot any unforeseen complications. Personal protective equipment should be donned and doffed in the presence of an assistant (ie, “buddy” system).

BACKGROUND

Acute hypoxemic respiratory failure or acute respiratory distress syndrome (ARDS) is a common and serious complication of COVID-19 infection.1 Approximately 12% to 15% of these hospitalized patients need invasive ventilation via endotracheal intubation. In retrospective studies of COVID-19 patients, the onset of respiratory distress occurred late (median of 6.5 days) after symptom onset but progressed rapidly to ARDS (median of 2.5 days).1–3 Timely intubation prevents oxygen debt by optimizing oxygenation and ventilation.4

Endotracheal intubation is a critical procedure in the management of unstable patients with COVID-19. However, rapid decompensation and hypoxemia have been observed during intubation from pulmonary derecruitment. Intubation can be associated with hemodynamic compromise from sympatholysis, vasodilation, and myocardial depression caused by induction agents. Intubation is an aerosol-generating procedure and is associated with a high risk of trans mission to health care workers. Of all aerosol generating procedures, tracheal intubation is most consistently associated with disease transmission with an odds ratio of 6.6 and an absolute risk increase between 10% and 15%.5 Adequate preparation is paramount for the safety of the patient and providers. Table 1 outlines the key steps for health care providers to take before, during, and after intubation.

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TABLE 1

Guidelines for performing endotracheal intubation in patients with COVID-19

PREINTUBATION CONSIDERATIONS

The indications for intubation in patients with respiratory distress due to COVID-19 are similar to those in patients without the infection. However, patients with COVID -19 tend to deteriorate rapidly, warranting timely intubation.6 Ideally, patients are intubated in a controlled environment, such as an intensive care unit, but this may not always be feasible, and such a scenario should be anticipated. Noninvasive ventilation is associated with increased risk of aerosolization and should be avoided when transporting patients.

According to guidelines from the Centers of Disease Control and Management, appropriate personal protective equipment (PPE) should by donned before airway management7 in the presence of an assistant (buddy system) to ensure proper protocol is followed. Only health care providers directly involved in the intubation procedure should enter the room. Extra providers (runners) can be stationed outside to assist if needed. This is of utmost importance to minimize the transmission of infection. Ideal teams typically include a physician performing the intubation with a skilled assistant, a registered nurse, and a respiratory therapist.

An intubation bag containing medications required for intubation, appropriate vasopressors, and post-intubation sedative infusions should be brought into the room. To address the risk of sudden decompensation during intubation, a defibrillator and ‘code box’ containing resuscitative medications should be stationed outside the room. There should be a ventilator available in the room so that patients can be promptly connected to minimize aerosol generation.

Intubation should be performed by the most experienced provider utilizing a video laryngoscope to minimize intubation time and the number of attempts. Use of a video laryngoscope versus a direct laryngoscope is associated with an increase in the distance between the health care worker and patient and thus may minimize the chances of cross infection. We recommend using a size 7.5 mm endotracheal tube for females and size 8.0 mm for males. Use of smaller sizes is associated with difficulty in ventilation and an increased likelihood of endotracheal tube obstruction with secretions.

Endotracheal tube obstruction caused by secretions is a common issue in patients with COVID-19 patients and may partly be related to the length of intubation as well as infrequent suctioning due to fear of contamination. Timely suctioning guided by the presence of secretions and the use of a humidifier can help prevent tube obstruction, which may require emergency tube exchange.

Airway equipment in the room should include a supraglottic airway device (eg, laryngeal mask airway or i-gel), gum-elastic bougie, and Magill forceps. Suction should be connected and be easily accessible to prevent aspiration once protective laryngeal reflexes are lost by induction medications. A reliable intravenous access should be established with a bag of intravenous fluid attached and running. Intubating conditions should be optimized, including bed height and patient position. All equipment including endotracheal tube should be pre-checked. A high efficiency particulate air (HEPA) or heat and moisture exchanger (HME) filter should be in the room with inline waveform capnography. If the patient has history of difficult intubation or if there are any signs of potential difficult airway, a team capable of performing emergency surgical airway in the event of difficult intubation and ventilation scenario should be available.

INTUBATION PROCEDURE

The aim of intubation is to rapidly secure the airway and minimize aerosol generation. Use of barrier devices, such as screens and intubation boxes (Figure 1), should be considered to prevent cross infection during intubation.3 A plastic sheet can be used if a screen and intubation box are not available.

Figure 1
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Figure 1

The AERO GUARD (C2Dx) barrier device.

Preoxygenation is best achieved by using a 100% non-rebreather mask on the patient for 3 to 5 minutes.4 Bag mask ventilation increases the risk of cross infection and should be administered only if absolutely necessary. Likewise, non-invasive ventilation should be avoided as a mode of preoxygenation due to concern of aerosol generation. However, if the patient is already on non-invasive ventilation, it should be continued.8

Short-acting opioids such fentanyl may induce coughing and should be avoided. Etomidate (0.2 to 0.3 mg/kg) can be used in hemodynamically unstable patients or propofol can be used as induction in hemodynamically stable patients. Other induction agents include ketamine and methohexital. Muscle relaxation is achieved by either rocuronium (1.2mg/kg) or succinylcholine (1.0 to 1.5 mg/kg).

Once the endotracheal tube is placed, it should be immediately connected to the ventilator/bag with an HME filter. The tube position can then be confirmed with tracing from inline waveform capnography.2,4 Breathing circuit disconnections should be avoided, and endotracheal tube clamping should be considered to prevent derecruitment and cross infection.

If any difficulty is encountered during intubation and ventilation is required, a supraglottic airway device should be placed to help in oxygenation and ventilation in preference to bag mask ventilation. When using a supraglottic device airway filter (HME, HEPA), it should be placed between the supraglottic device and Ambu bag. Due to risk of aerosolization, fiberoptic intubation is discouraged and if needed, a disposable bronchoscope should be used.

POSTINTUBATION

We suggest initial ventilator settings as:

  • Pressure-regulated volume control with tidal volume 6 to 8 mL/kg of ideal body weight

  • Plateau pressure < 30 cm H20

  • FiO2 1.0 (FiO2 should be titrated to SPO2 > 92%)

  • Respiratory rate 12 per minute.

Intravenous sedation should be started after intubation; choices include propofol and dexmedetomidine. Invasive lines can be placed after intubation if needed to reduce healthcare exposure and the need for additional radiographs beyond a chest film. All non-disposable equipment should be thoroughly cleaned according to infection control guidelines. Doffing and hand hygiene should be performed using a buddy system.

Footnotes

  • The statements and opinions expressed in COVID-19 Curbside Consults are based on experience and the available literature as of the date posted. While we try to regularly update this content, any offered recommendations cannot be substituted for the clinical judgment of clinicians caring for individual patients.

  • Copyright © 2020 The Cleveland Clinic Foundation. All Rights Reserved.

REFERENCES

  1. ↵
    1. Wang D,
    2. Hu B,
    3. Hu C, et al
    . Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020; 323(11):1061–1069. doi:10.1001/jama.2020.1585
    OpenUrlCrossRefPubMed
  2. ↵
    1. Yang X,
    2. Yu Y,
    3. Xu J, et al
    . Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. Published online Feb 24, 2020. doi:10.1016/S2213-2600(20)30079-5
    OpenUrlCrossRefPubMed
  3. ↵
    1. Canelli R,
    2. Connor CW,
    3. Gonzalez M,
    4. Nozari A,
    5. Ortega R
    . Barrier Enclosure during Endotracheal Intubation. N Engl J Med. Published online April 3, 2020. doi:10.1056/nejmc2007589
    OpenUrlCrossRef
  4. ↵
    1. Shoemaker WC,
    2. Appel PL,
    3. Kram HB
    . Role of oxygen debt in the development of organ failure sepsis, and death in high-risk surgical patients. Chest 1992; 102(1):208–215. doi:10.1378/chest.102.1.208
    OpenUrlCrossRefPubMed
  5. ↵
    1. Tran K,
    2. Cimon K,
    3. Severn M,
    4. Pessoa-Silva CL,
    5. Conly J
    . Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review. PLoS One 2012; 7(4):e35797. doi:10.1371/journal.pone.0035797
    OpenUrlCrossRefPubMed
  6. ↵
    1. Meng L,
    2. Qiu H,
    3. Wan L, et al
    . Intubation and Ventilation amid the COVID-19 Outbreak: Wuhan’s Experience. Anesthesiology. Published online March 26, 2020. doi:10.1097/ALN.0000000000003296
    OpenUrlCrossRef
  7. ↵
    Use of Personal Protective Equipment (PPE) When Caring for Patients with Confirmed or Suspected COVID-19. Centers for Disease Control and Prevention. www.cdc.gov/coronavirus/2019-ncov/downloads/A_FS_HCP_COVID19_PPE.pdf. Accessed May 7, 2020.
  8. ↵
    1. Baillard C,
    2. Prat G,
    3. Jung B, et al
    . Effect of preoxygenation using noninvasive ventilation before intubation on subsequent organ failures in hypoxaemic patients: A randomised clinical trial. Br J Anaesth 2018; 120(2):361–367. doi:10.1016/j.bja.2017.11.067
    OpenUrlCrossRef
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Cleveland Clinic Journal of Medicine: 90 (6)
Cleveland Clinic Journal of Medicine
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Airway management considerations in patients with COVID-19
Praveen Chahar, Sidharth Dugar, Donn Marciniak
Cleveland Clinic Journal of Medicine May 2020, DOI: 10.3949/ccjm.87a.ccc033

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Airway management considerations in patients with COVID-19
Praveen Chahar, Sidharth Dugar, Donn Marciniak
Cleveland Clinic Journal of Medicine May 2020, DOI: 10.3949/ccjm.87a.ccc033
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