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COVID-19 Curbside Consults

Treating acute anxiety in patients with COVID-19

Elias Khawam, MD, Hassan Khouli, MD and Leo Pozuelo, MD
Cleveland Clinic Journal of Medicine May 2020, DOI: https://doi.org/10.3949/ccjm.87a.ccc016
Elias Khawam
Department of Psychiatry and Psychology, Neurologic Institute, Cleveland Clinic
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Hassan Khouli
Department of Critical Care Medicine, Respiratory Institute, Cleveland Clinic
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Leo Pozuelo
Department of Psychiatry and Psychology, Neurologic Institute, Cleveland Clinic
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    TABLE 1

    Medications for the treatment of acute anxiety in hospitalized patients with COVID-19 infection

    MedicationDoseRouteCaution
    Alprazolam0.125–0.25 mg,3 times dailyBy mouthRespiratory depression
    Lorazepam0.5–1 mg, 3 times dailyBy mouth, intramuscular, intravenousaRespiratory depression
    Gabapentin100–300 mg, 3 times dailyBy mouthRenal clearance
    Hydroxyzine25–50 mg, 3 times dailyBy mouthQTc monitoring
    Olanzapine2.5–5 mg, 3 times dailyBy mouthQTc monitoring
    Quetiapine25–50 mg, 3 times dailyBy mouthQTc monitoring
    Haloperidol0.5–1 mg, 3 times dailyBy mouth, intramuscular, intravenousaQTc monitoring
    • ↵a For intravenous dosing, use half of the oral dose.

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Cleveland Clinic Journal of Medicine: 92 (5)
Cleveland Clinic Journal of Medicine
Vol. 92, Issue 5
1 May 2025
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Treating acute anxiety in patients with COVID-19
Elias Khawam, Hassan Khouli, Leo Pozuelo
Cleveland Clinic Journal of Medicine May 2020, DOI: 10.3949/ccjm.87a.ccc016

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Treating acute anxiety in patients with COVID-19
Elias Khawam, Hassan Khouli, Leo Pozuelo
Cleveland Clinic Journal of Medicine May 2020, DOI: 10.3949/ccjm.87a.ccc016
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