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Supportive care37,38 Fluid and salt intake (eg, soup, broth, juice, saltine crackers, low carbohydrate sports drinks) to maintain hydration status Oral rehydration therapy for mild dehydration Intravenous rehydration for severe dehydration Pharmacotherapy37,38 Nausea and vomiting: • Prochlorperazine 5 to 10 mg orally 3 to 4 times daily as needed (maximum of 40 mg/day) • Ondansetron 4 to 8 mg orally 3 times daily as needed (off-label use) Diarrhea: • Loperamide 4 mg orally initially, followed by 2 mg after each watery stool (maximum of 8 mg/day) Monitoring for worsening disease course39 Hospitalization if alarm symptoms: • Severe or persistent symptoms • Gastrointestinal bleeding • Intractable vomiting • Dehydration • Change in mental status Consider consultation with a gastroenterologist for further work-up and management if worsening disease course.
