Epilepsy
- Pathogenesis of epilepsy: the role of excitatory amino acids
These neurotransmitters seem to play a role in brain development—and also in seizures. Experimental drugs can block their action.
- Antiepileptic drug therapy in younger patients: when to start, when to stop
Recent studies suggest that antiepileptic drug therapy can be discontinued in many young patients after a 2-year seizure-free interval.
- Recurrence, remission, and relapse of seizures
Drug treatment after a first seizure reduces the risk of recurrence by about half, but many patients find the adverse effects intolerable.
- Experimental limbic epilepsy: models, pathophysiologic concepts, and clinical relevance
Complex partial seizures originating in the temporal lobe are common in epilepsy patients. Drug treatment is often ineffective. What predisposes a patient to these seizures? How do they occur? Animal studies are providing clues to the puzzle.