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I. Epilepsy: Current Concepts in Diagnosis and Treatment

Basic mechanisms of epileptic seizures

Larry S. Benardo, Ph.D. and Timothy A. Pedley, M.D.
Cleveland Clinic Journal of Medicine June 1984, 51 (2) 195-203;
Larry S. Benardo
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Timothy A. Pedley
Department of Neurology and The Neurological Institute, Columbia University College of Physicians and Surgeons, New York
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ABSTRACT

The results of recent experimental studies continue to enhance the understanding of basic mechanisms involved in epileptogenesis. Intracellular recordings from both in vivo and in vitro preparations have defined essential elements that underlie the pathologic firing patterns characteristic of "epileptic neurons." Generation of epileptogenic discharges depends on the interplay of three major factors: (1) the inherent capacity of some neurons to elaborate active responses that lead to paroxysmal bursting; (2) the breakdown of normal inhibitory mechanisms and the augmentation of excitatory synaptic activities; and (3) the biasing effect on these processes of modulating neurotransmitter substances which help to maintain pathologic discharges. Differences between acute and chronic foci probably depend more on the degree and intensity of these factors than on fundamentally different mechanisms.

Index terms
  • Epilepsy
  • Neuroregulators
  • Seizures
  • Received October 1983.
  • Accepted October 1983.
  • Copyright © 1984 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 51 (2)
Cleveland Clinic Journal of Medicine
Vol. 51, Issue 2
20 Jun 1984
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Basic mechanisms of epileptic seizures
Larry S. Benardo, Timothy A. Pedley
Cleveland Clinic Journal of Medicine Jun 1984, 51 (2) 195-203;

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Basic mechanisms of epileptic seizures
Larry S. Benardo, Timothy A. Pedley
Cleveland Clinic Journal of Medicine Jun 1984, 51 (2) 195-203;
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More in this TOC Section

I. Epilepsy: Current Concepts in Diagnosis and Treatment

  • Febrile convulsions: a new look at an old problem
  • Antiepileptic Drug Development Program
  • Differential diagnosis and treatment of intractable seizures
Show more I. Epilepsy: Current Concepts in Diagnosis and Treatment

Contributions

  • Febrile convulsions: a new look at an old problem
  • Antiepileptic Drug Development Program
  • Differential diagnosis and treatment of intractable seizures
Show more Contributions

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Keywords

  • Epilepsy
  • Neuroregulators
  • SEIZURES

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