Most cited article(s)
- Meta-analysis: Its strengths and limitations
Meta-analysis is powerful but also controversial, because several conditions are critical to a sound meta-analysis, and small violations of those conditions can produce misleading results.
- Primary angiitis of the central nervous system: diagnostic criteria and clinical approach
Clinical perceptions of PACNS have changed dramatically in the last 5 years, prompting a reappraisal of the 1987 diagnostic criteria and current approaches to treatment
- Role of uric acid in hypertension, renal disease, and metabolic syndrome
Clinical gout is just the tip of the iceberg: we believe that elevated uric acid is actually one of the most important risk factors for cardiovascular disease and that it plays a role in renal disease and metabolic syndrome as well.
- Frailty in older adults: Implications for end-of-life care
By recognizing and measuring frailty, clinicians can better engage patients and their loved ones in difficult discussions about prognoses and plans, and can ultimately give better palliative care.
- Statin myopathy: A common dilemma not reflected in clinical trials
When a patient taking a statin complains of muscle aches, is he or she experiencing statin-induced myopathy or some other problem? Should the statin be discontinued?
- Cytokine storm and the prospects for immunotherapy with COVID-19
Despite gaping holes in our knowledge, treatment is evolving.
- Diffuse alveolar hemorrhage: Diagnosing it and finding the cause
Diffuse alveolar hemorrhage can complicate a large number of clinical conditions. It may present in different ways and may be life-threatening, and it poses an important challenge for the clinician.