Most cited article(s)

  • Meta-analysis: Its strengths and limitations

    Esteban Walker, PhD, Adrian V. Hernandez, MD, PhD and Michael W. Kattan, PhD
    • Cleveland Clinic Journal of Medicine June 2008, 75 (6) 431-439;

    • Meta-analysis is powerful but also controversial, because several conditions are critical to a sound meta-analysis, and small violations of those conditions can produce misleading results.

  • Primary angiitis of the central nervous system: diagnostic criteria and clinical approach

    Leonard H. Calabrese, DO, Anthony J. Furlan, MD, Lisa A. Gragg, MS and Trumane J. Ropos, DO
    • Cleveland Clinic Journal of Medicine May 1992, 59 (3) 293-306;

    • Clinical perceptions of PACNS have changed dramatically in the last 5 years, prompting a reappraisal of the 1987 diagnostic criteria and current approaches to treatment

  • The essential role of exercise in the management of type 2 diabetes

    John P. Kirwan, PhD, Jessica Sacks and Stephan Nieuwoudt
    • Cleveland Clinic Journal of Medicine July 2017, 84 (7 suppl 1) S15-S21;
    • DOI: https://doi.org/10.3949/ccjm.84.s1.03

  • Role of uric acid in hypertension, renal disease, and metabolic syndrome

    Marcelo Heinig, MD and Richard J. Johnson, MD
    • Cleveland Clinic Journal of Medicine December 2006, 73 (12) 1059-1064;

    • Clinical gout is just the tip of the iceberg: we believe that elevated uric acid is actually one of the most important risk factors for cardiovascular disease and that it plays a role in renal disease and metabolic syndrome as well.

  • Physical and social impact of alpha 1-antitrypsin deficiency: results of a survey

    James K. Stoller, MD, Peter Smith, Peter Yang, MS and Judy Spray, PhD
    • Cleveland Clinic Journal of Medicine November 1994, 61 (6) 461-467;

  • Frailty in older adults: Implications for end-of-life care

    Katalin Koller, MD, FRCP and Kenneth Rockwood, MD, FRCPC, FRCP
    • Cleveland Clinic Journal of Medicine March 2013, 80 (3) 168-174;
    • DOI: https://doi.org/10.3949/ccjm.80a.12100

    • By recognizing and measuring frailty, clinicians can better engage patients and their loved ones in difficult discussions about prognoses and plans, and can ultimately give better palliative care.

  • Diffuse alveolar hemorrhage: Diagnosing it and finding the cause

    Octavian C. Ioachimescu, MD and James K. Stoller, MD
    • Cleveland Clinic Journal of Medicine April 2008, 75 (4) 258-280;

    • Diffuse alveolar hemorrhage can complicate a large number of clinical conditions. It may present in different ways and may be life-threatening, and it poses an important challenge for the clinician.

  • Statin myopathy: A common dilemma not reflected in clinical trials

    Genaro Fernandez, MD, Erica S. Spatz, MD, Charles Jablecki, MD and Paul S. Phillips, MD
    • Cleveland Clinic Journal of Medicine June 2011, 78 (6) 393-403;
    • DOI: https://doi.org/10.3949/ccjm.78a.10073

    • When a patient taking a statin complains of muscle aches, is he or she experiencing statin-induced myopathy or some other problem? Should the statin be discontinued?

  • Cytokine storm and the prospects for immunotherapy with COVID-19

    Leonard H. Calabrese, DO
    • Cleveland Clinic Journal of Medicine July 2020, 87 (7) 389-393;
    • DOI: https://doi.org/10.3949/ccjm.87a.ccc008

    • Despite gaping holes in our knowledge, treatment is evolving.

  • Approach to asymptomatic creatine kinase elevation

    Siamak Moghadam-Kia, MD, Chester V. Oddis, MD and Rohit Aggarwal, MD, MS
    • Cleveland Clinic Journal of Medicine January 2016, 83 (1) 37-42;
    • DOI: https://doi.org/10.3949/ccjm.83a.14120

    • Standard cutoffs may be too low. First, repeat the test after 7 days without exercise.

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