Most cited article(s)

  • Meta-analysis: Its strengths and limitations
    Esteban Walker, PhD, Adrian V. Hernandez, MD, PhD and Michael W. Kattan, PhD
    Cleveland Clinic Journal of Medicine June 2008, 75 (6) 431-439;

    Meta-analysis is powerful but also controversial, because several conditions are critical to a sound meta-analysis, and small violations of those conditions can produce misleading results.

  • Primary angiitis of the central nervous system: diagnostic criteria and clinical approach
    Leonard H. Calabrese, DO, Anthony J. Furlan, MD, Lisa A. Gragg, MS and Trumane J. Ropos, DO
    Cleveland Clinic Journal of Medicine May 1992, 59 (3) 293-306;

    Clinical perceptions of PACNS have changed dramatically in the last 5 years, prompting a reappraisal of the 1987 diagnostic criteria and current approaches to treatment

  • Role of uric acid in hypertension, renal disease, and metabolic syndrome
    Marcelo Heinig, MD and Richard J. Johnson, MD
    Cleveland Clinic Journal of Medicine December 2006, 73 (12) 1059-1064;

    Clinical gout is just the tip of the iceberg: we believe that elevated uric acid is actually one of the most important risk factors for cardiovascular disease and that it plays a role in renal disease and metabolic syndrome as well.

  • Physical and social impact of alpha 1-antitrypsin deficiency: results of a survey
    James K. Stoller, MD, Peter Smith, Peter Yang, MS and Judy Spray, PhD
    Cleveland Clinic Journal of Medicine November 1994, 61 (6) 461-467;
  • Statin myopathy: A common dilemma not reflected in clinical trials
    Genaro Fernandez, MD, Erica S. Spatz, MD, Charles Jablecki, MD and Paul S. Phillips, MD
    Cleveland Clinic Journal of Medicine June 2011, 78 (6) 393-403; DOI: https://doi.org/10.3949/ccjm.78a.10073

    When a patient taking a statin complains of muscle aches, is he or she experiencing statin-induced myopathy or some other problem? Should the statin be discontinued?

  • Frailty in older adults: Implications for end-of-life care
    Katalin Koller, MD, FRCP and Kenneth Rockwood, MD, FRCPC, FRCP
    Cleveland Clinic Journal of Medicine March 2013, 80 (3) 168-174; DOI: https://doi.org/10.3949/ccjm.80a.12100

    By recognizing and measuring frailty, clinicians can better engage patients and their loved ones in difficult discussions about prognoses and plans, and can ultimately give better palliative care.

  • Cytokine storm and the prospects for immunotherapy with COVID-19
    Leonard H. Calabrese, DO
    Cleveland Clinic Journal of Medicine July 2020, 87 (7) 389-393; DOI: https://doi.org/10.3949/ccjm.87a.ccc008

    Despite gaping holes in our knowledge, treatment is evolving.

  • Coronary artery bypass graft surgery in the elderly
    Floyd D. Loop, MD, Bruce W. Lytle, MD, Delos M. Cosgrove, MD, Marlene Goormastic, MPH, Paul C. Taylor, MD, Leonard A. R. Golding, MD, Robert W. Stewart, MD and Carl C. Gill, MD
    Cleveland Clinic Journal of Medicine January 1988, 55 (1) 23-34;
  • Late results of coronary bypass in patients with peripheral vascular disease
    Norman R. Hertzer, M.D., Jess R. Young, M.D., Edwin G. Bevett, M.D., Patrick J. O’Hara, M.D., Robert A. Graor, M.D., William F. Ruschhaupt, M.D. and Linda C. Maljovec, B.A.
    Cleveland Clinic Journal of Medicine January 1987, 54 (1) 15-23;
  • Doppler echocardiographic assessment of constrictive pericarditis, cardiac amyloidosis, and cardiac tamponade
    Allan L. Klein, MD and Gerald I. Cohen, MD
    Cleveland Clinic Journal of Medicine May 1992, 59 (3) 278-290;

    Doppler echocardiography is emerging as an excellent noninvasive way to assess diastolic function, and its array of clinical applications is expanding.

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