Most cited article(s)
- Meta-analysis: Its strengths and limitations
Meta-analysis is powerful but also controversial, because several conditions are critical to a sound meta-analysis, and small violations of those conditions can produce misleading results.
- Primary angiitis of the central nervous system: diagnostic criteria and clinical approach
Clinical perceptions of PACNS have changed dramatically in the last 5 years, prompting a reappraisal of the 1987 diagnostic criteria and current approaches to treatment
- Role of uric acid in hypertension, renal disease, and metabolic syndrome
Clinical gout is just the tip of the iceberg: we believe that elevated uric acid is actually one of the most important risk factors for cardiovascular disease and that it plays a role in renal disease and metabolic syndrome as well.
- Frailty in older adults: Implications for end-of-life care
By recognizing and measuring frailty, clinicians can better engage patients and their loved ones in difficult discussions about prognoses and plans, and can ultimately give better palliative care.
- Statin myopathy: A common dilemma not reflected in clinical trials
When a patient taking a statin complains of muscle aches, is he or she experiencing statin-induced myopathy or some other problem? Should the statin be discontinued?
- Diffuse alveolar hemorrhage: Diagnosing it and finding the cause
Diffuse alveolar hemorrhage can complicate a large number of clinical conditions. It may present in different ways and may be life-threatening, and it poses an important challenge for the clinician.
- Cytokine storm and the prospects for immunotherapy with COVID-19
Despite gaping holes in our knowledge, treatment is evolving.
- Doppler echocardiographic assessment of constrictive pericarditis, cardiac amyloidosis, and cardiac tamponade
Doppler echocardiography is emerging as an excellent noninvasive way to assess diastolic function, and its array of clinical applications is expanding.