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Review

Initial studies with FK506 in renal transplantation

Mark L. Jordan, MD, Ron Shapiro, MD, John Fung, MD, PhD, Andreas Tzakis, MD, Saturo Todo, MD, Shimon Kusne, MD, Jake Demetrius, MD, Thomas R. Hakala, MD and Thomas E. Starzl, MD, PhD
Cleveland Clinic Journal of Medicine September 1991, 58 (5) 444-446;
Mark L. Jordan
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Ron Shapiro
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John Fung
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Andreas Tzakis
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Saturo Todo
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Shimon Kusne
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Jake Demetrius
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Thomas R. Hakala
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Thomas E. Starzl
Division of Urologie Surgery/Renal Transplantation Department of Surgery, University of Pittsburgh.
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ABSTRACT

FK506 is a novel immunosuppressive agent which is approximately 100 times as potent as cyclosporine in vitro. In this initial trial, 65 renal transplant patients of high complexity received primary FK506 immunosuppression. Overall, graft and patient survival rates are 80% and 98.5%, respectively. A major advantage of FK506 is its potency with relatively few side effects, which has permitted elimination of steroids in 31 (60%) of these patients. Because of these encouraging results, a randomized trial comparing the therapeutic efficacy and toxicity of FK506 and cyclosporine is currently underway at our institution.

INDEX TERMS
  • Antibiotics
  • Macrolide
  • Immunosuppressive Aoents
  • Kidney Transplantation
  • Cyclosporines
  • Copyright © 1991 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 58 (5)
Cleveland Clinic Journal of Medicine
Vol. 58, Issue 5
1 Sep 1991
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Initial studies with FK506 in renal transplantation
Mark L. Jordan, Ron Shapiro, John Fung, Andreas Tzakis, Saturo Todo, Shimon Kusne, Jake Demetrius, Thomas R. Hakala, Thomas E. Starzl
Cleveland Clinic Journal of Medicine Sep 1991, 58 (5) 444-446;

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Initial studies with FK506 in renal transplantation
Mark L. Jordan, Ron Shapiro, John Fung, Andreas Tzakis, Saturo Todo, Shimon Kusne, Jake Demetrius, Thomas R. Hakala, Thomas E. Starzl
Cleveland Clinic Journal of Medicine Sep 1991, 58 (5) 444-446;
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Keywords

  • Antibiotics
  • Macrolide
  • Immunosuppressive Aoents
  • KIDNEY TRANSPLANTATION
  • Cyclosporines

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