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Original Contribution

Cytogenetics of acute leukemia in 90 children and young adults

Prognostic value of karyotypic status at diagnosis

Gerald A. Hoeltge, M.D., Marilyn L. Slovak, M.T., Judith R. Leatherman, B.S. and Donald G. Norris, M.D.
Cleveland Clinic Journal of Medicine September 1983, 50 (3) 283-290;
Gerald A. Hoeltge
Cytogenetics Laboratory, The Cleveland Clinic Foundation.
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Marilyn L. Slovak
Cytogenetics Laboratory, The Cleveland Clinic Foundation.
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Judith R. Leatherman
Department of Biostatistics, The Cleveland Clinic Foundation.
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Donald G. Norris
Center for Children and Youth, Section on Hematology and Oncology, The Cleveland Clinic Foundation.
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ABSTRACT

The karyotypic abnormalities of 90 children and young adults with acute leukemia presenting at The Cleveland Clinic Foundation during a ten-year period are summarized. There was an inverse relationship between age and survival as well as an association between type of leukemia and survival. Certain cytogenetic abnormalities were also associated with an unfavorable prognosis. Both pseudodiploidy and the presence of an unidentifiable marker chromosome were determined to have a median survival of five months. Pseudodiploidy may be characterized by specific translocations such as t(8;14), t(4;ll), t(9;22), and t(15;17), which are associated with clinical subgroups of acute leukemia known to be poorly responsive to therapy. Conversely, hyperdiploidy and normal diploidy in childhood leukemia determined a subgroup of patients with a median survival of 30 months.

Index terms
  • Chromosome abnormalities
  • Genetics
  • medical
  • Leukemia
  • familial and genetic
  • Received May 1983.
  • Accepted June 1983.
  • Copyright © 1983 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 50 (3)
Cleveland Clinic Journal of Medicine
Vol. 50, Issue 3
21 Sep 1983
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Cytogenetics of acute leukemia in 90 children and young adults
Gerald A. Hoeltge, Marilyn L. Slovak, Judith R. Leatherman, Donald G. Norris
Cleveland Clinic Journal of Medicine Sep 1983, 50 (3) 283-290;

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Cytogenetics of acute leukemia in 90 children and young adults
Gerald A. Hoeltge, Marilyn L. Slovak, Judith R. Leatherman, Donald G. Norris
Cleveland Clinic Journal of Medicine Sep 1983, 50 (3) 283-290;
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Keywords

  • Chromosome abnormalities
  • Genetics
  • Medical
  • LEUKEMIA
  • Familial and Genetic

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