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Case Report

Combined desmopressin (DDAVP) and chlorpropamide therapy for diabetes insipidus with absent thirst

Geoffrey P. Redmond, M.D., A. David Rothner, M.D., Joseph F. Hahn, M.D. and O. Peter Schumacher, M.D., Ph.D.
Cleveland Clinic Journal of Medicine September 1983, 50 (3) 351-352;
Geoffrey P. Redmond
Department of Pediatric and Adolescent Medicine, The Cleveland Clinic Foundation.
Department of Endocrinology, The Cleveland Clinic Foundation.
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A. David Rothner
Department of Pediatric and Adolescent Medicine, The Cleveland Clinic Foundation.
Department of Neurology, The Cleveland Clinic Foundation.
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Joseph F. Hahn
Department of Neurological Surgery, The Cleveland Clinic Foundation.
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O. Peter Schumacher
Department of Endocrinology, The Cleveland Clinic Foundation.
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ABSTRACT

A patient with neurogenic diabetes insipidus and defective thirst regulation due to a craniopharyngioma is described who responded to a combination of desmopressin (DDAVP) and chlorpropamide with improved thirst regulation and decreased urine output. When DDAVP was discontinued he became hypernatremic. This patient required both DDAVP and chlorpropamide to maintain normonatremia.

Index terms
  • Brain neoplasms
  • Chlorpropamide
  • Craniopharyngioma
  • Desmopressin (DDAVP)
  • Diabetes insipidus
  • Received May 1983.
  • Accepted June 1983.
  • Copyright © 1983 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 50 (3)
Cleveland Clinic Journal of Medicine
Vol. 50, Issue 3
21 Sep 1983
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Combined desmopressin (DDAVP) and chlorpropamide therapy for diabetes insipidus with absent thirst
Geoffrey P. Redmond, A. David Rothner, Joseph F. Hahn, O. Peter Schumacher
Cleveland Clinic Journal of Medicine Sep 1983, 50 (3) 351-352;

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Combined desmopressin (DDAVP) and chlorpropamide therapy for diabetes insipidus with absent thirst
Geoffrey P. Redmond, A. David Rothner, Joseph F. Hahn, O. Peter Schumacher
Cleveland Clinic Journal of Medicine Sep 1983, 50 (3) 351-352;
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Keywords

  • Brain Neoplasms
  • Chlorpropamide
  • Craniopharyngioma
  • Desmopressin (DDAVP)
  • Diabetes insipidus

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