Combined desmopressin (DDAVP) and chlorpropamide therapy for diabetes insipidus with absent thirst

  • Cleveland Clinic Journal of Medicine
  • September 1983,
  • 50
  • (3)
  • 351-352;

ABSTRACT

A patient with neurogenic diabetes insipidus and defective thirst regulation due to a craniopharyngioma is described who responded to a combination of desmopressin (DDAVP) and chlorpropamide with improved thirst regulation and decreased urine output. When DDAVP was discontinued he became hypernatremic. This patient required both DDAVP and chlorpropamide to maintain normonatremia.

Index terms
  • Received May 1983.
  • Accepted June 1983.
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