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I. Epilepsy: Current Concepts in Diagnosis and Treatment

Antiepileptic Drug Development Program

Roger J. Porter, M.D., James J. Cereghino, M.D., Gill D. Gladding, R.Ph., Bettiejean Hessie, B.S., Harvey J. Kupferberg, Ph.D., Barrett Scoville, M.D. and Billy G. White, Ph.D.
Cleveland Clinic Journal of Medicine June 1984, 51 (2) 293-305;
Roger J. Porter
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James J. Cereghino
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Gill D. Gladding
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Bettiejean Hessie
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Harvey J. Kupferberg
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Barrett Scoville
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Billy G. White
Epilepsy Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD.
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ABSTRACT

The modern era of antiepileptic drug therapy began with the use of phenobarbital in 1912. In the years thereafter, many new drugs were introduced, including other barbiturates, hydantoins, succinimides, and oxazolidinediones. Then, for various reasons, the marketing of new antiepileptic drugs was dramatically curtailed. To help reverse this trend, the Epilepsy Branch of the National Institute of Neurological and Communicative Disorders and Stroke sponsored clinical trials of drugs which had already been marketed abroad, resulting in the distribution of clonazepam, carbamazepine, and valproic acid in the U.S. These trials were followed by the establishment of the Antiepileptic Drug Development Program, which encompasses both the preclinical and clinical elements of drug development, including the Anticonvulsant Screening Project, the Toxicology Project, and support for controlled clinical trials.

Index terms
  • Anticonvulsants
  • Epilepsy
  • Received October 1983.
  • Accepted October 1983.
  • Copyright © 1984 The Cleveland Clinic Foundation. All Rights Reserved.

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Cleveland Clinic Journal of Medicine: 51 (2)
Cleveland Clinic Journal of Medicine
Vol. 51, Issue 2
20 Jun 1984
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Antiepileptic Drug Development Program
Roger J. Porter, James J. Cereghino, Gill D. Gladding, Bettiejean Hessie, Harvey J. Kupferberg, Barrett Scoville, Billy G. White
Cleveland Clinic Journal of Medicine Jun 1984, 51 (2) 293-305;

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Antiepileptic Drug Development Program
Roger J. Porter, James J. Cereghino, Gill D. Gladding, Bettiejean Hessie, Harvey J. Kupferberg, Barrett Scoville, Billy G. White
Cleveland Clinic Journal of Medicine Jun 1984, 51 (2) 293-305;
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More in this TOC Section

I. Epilepsy: Current Concepts in Diagnosis and Treatment

  • Evaluation of the child with seizures
  • Febrile convulsions: a new look at an old problem
Show more I. Epilepsy: Current Concepts in Diagnosis and Treatment

Contributions

  • Evaluation of the child with seizures
  • Febrile convulsions: a new look at an old problem
  • Panic disorder and social phobia: Current treatments and new strategies
Show more Contributions

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Keywords

  • Anticonvulsants
  • Epilepsy

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