Donor blood-count changes during and after plateletpheresis

ABSTRACT

Thirty-two platelet donors at the Cleveland Clinic Foundation were monitored for white blood cell count, leukocyte differential, red blood cell count, and platelet count before, during, and after the collection of platelets. Counts were performed at 15-minute intervals during plateletpheresis using the Fenwal CS 3000 cell separator and at the beginning of each draw cycle using the Haemonetics V50 cell separator. Red blood cell concentration declined significantly (p < 0.05). Leukocyte counts decreased initially (p < 0.05), followed by a secondary rise, and reached a plateau below the initial value. Platelet counts declined steadily with a net loss comparable to the platelet yield. Platelet collection efficiencies on the two machines were not significantly different.