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Contribution

Acquired factor X deficiency in systemic amyloidosis

Fred V. Lucas, M.D., Andrew J. Fishleder, M.D., Richard C. Becker, M.D., Deborah S. Cavalier, M.D. and Raymond R. Tubbs, D.O.
Cleveland Clinic Journal of Medicine September 1987, 54 (5) 399-406;
Fred V. Lucas
Department of Laboratory Hematology, The Cleveland Clinic Foundation
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Andrew J. Fishleder
Department of Laboratory Hematology, The Cleveland Clinic Foundation
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Richard C. Becker
Department of Internal Medicine, The Cleveland Clinic Foundation
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Deborah S. Cavalier
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Raymond R. Tubbs
Department of Pathology, The Cleveland Clinic Foundation
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ABSTRACT

Acquired factor X deficiency has been described in association with primary amyloidosis in a small number of patients. Although readily corrected in vitro by mixing patient plasma with normal plasma, the deficiency is not easily corrected in vivo because transfused factor X is rapidly cleared from the circulation. It has been suggested that the mechanism underlying this phenomenon may be the selective binding of factor X to amyloid and its consequent removal from the circulation. Two cases of primary amyloidosis and coexistent acquired factor X deficiency are reported. Immunostains for factor X and immunoglobulin light chains showed the coagulation factor in the region of the amyloid deposits. The findings directly support the hypothesis that factor X deficiency in primary amyloidosis is caused by clearance of factor X by binding to amyloid fibrils.

Index terms
  • Amyloidosis
  • Factor X
  • Received February 1987.
  • Accepted May 1987.
  • Copyright © 1987 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 54 (5)
Cleveland Clinic Journal of Medicine
Vol. 54, Issue 5
1 Sep 1987
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Acquired factor X deficiency in systemic amyloidosis
Fred V. Lucas, Andrew J. Fishleder, Richard C. Becker, Deborah S. Cavalier, Raymond R. Tubbs
Cleveland Clinic Journal of Medicine Sep 1987, 54 (5) 399-406;

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Acquired factor X deficiency in systemic amyloidosis
Fred V. Lucas, Andrew J. Fishleder, Richard C. Becker, Deborah S. Cavalier, Raymond R. Tubbs
Cleveland Clinic Journal of Medicine Sep 1987, 54 (5) 399-406;
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Keywords

  • Amyloidosis
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