ABSTRACT
The authors describe a 58-year-old woman who experienced an erythema multiforme-like reaction following therapy with cefamandole naftate. Histologically, findings were consistent with erythema multiforme, but diffuse linear deposition of IgA was demonstrated at the dermo-epidermal junction by direct immunofluorescence. Ultrastructurally, deposits were located beneath the basal lamina, around the anchoring fibrils. These observations illustrate that adult linear IgA bullous dermatosis can mimic the clinical and histological features of erythema multiforme and suggest the possibility of drug-induced pathogenesis.
- Received February 1987.
- Accepted May 1987.
- Copyright © 1987 The Cleveland Clinic Foundation. All Rights Reserved.