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Case Report

Treatment of metastatic transitional cell carcinoma following renal transplantation

David P. Wood, MD, Andrew C. Novick, MD, Douglas E. Johnson, MD, Stevan B. Streem, MD and Donald Steinmuller, MD
Cleveland Clinic Journal of Medicine January 1989, 56 (1) 61-63;
David P. Wood Jr.
Department of Urology, The Cleveland Clinic Foundation
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Andrew C. Novick
Department of Urology, The Cleveland Clinic Foundation
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Douglas E. Johnson
Department of M. D. Anderson Hospital and Tumor Institute
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Stevan B. Streem
Department of Urology, The Cleveland Clinic Foundation
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Donald Steinmuller
Department of Urology, The Cleveland Clinic Foundation
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ABSTRACT

Renal transplantation was performed in a patient with a history of surgical excision for localized transitional cell carcinoma. The graft functioned well; however, metastatic transitional cell carcinoma developed following transplantation. The patient was treated sequentially with CISCA (cisplatin, Cy-toxan [cyclophosphamide], and Adriamycin [doxorubicin hydrochloride]) and M-VAC (methotrexate, vinblastine, Adriamycin, and cisplatin) with no alteration in maintenance immunosuppression. Full-dose chemotherapy was well tolerated, with no impairment of renal function, and a demonstrable reduction in tumor burden was achieved. The patient ultimately died of metastatic disease but enjoyed an excellent quality of life throughout the post-transplant period.

INDEX TERMS
  • Kidney
  • Transplantation
  • Transplantation
  • Complications
  • Received November 1987.
  • Accepted July 1988.
  • Copyright © 1989 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 56 (1)
Cleveland Clinic Journal of Medicine
Vol. 56, Issue 1
1 Jan 1989
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Treatment of metastatic transitional cell carcinoma following renal transplantation
David P. Wood, Andrew C. Novick, Douglas E. Johnson, Stevan B. Streem, Donald Steinmuller
Cleveland Clinic Journal of Medicine Jan 1989, 56 (1) 61-63;

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Treatment of metastatic transitional cell carcinoma following renal transplantation
David P. Wood, Andrew C. Novick, Douglas E. Johnson, Stevan B. Streem, Donald Steinmuller
Cleveland Clinic Journal of Medicine Jan 1989, 56 (1) 61-63;
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Keywords

  • Kidney
  • TRANSPLANTATION
  • Complications

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