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Contributions

Comparative activity of newer antibiotics against gram-negative bacilli

Cynthia C. Knapp, MS and John A. Washington, MD
Cleveland Clinic Journal of Medicine March 1989, 56 (2) 161-166;
Cynthia C. Knapp
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John A. Washington
Department of Microbiology, The Cleveland Clinic Foundation
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ABSTRACT

The in vitro activities of cefoperazone, cefotaxime, ceftriaxone, ceftazidime, azlocillin, mezlocillin, piperacillin, ticarcillin/clavulanate, aztreonam, imipenem, and ciprofloxacin were concurrently determined against over 1,000 isolates of gram-negative bacilli from clinical specimens of patients at the Cleve-land Clinic. Cephalosporins, penicillins, and aztreonam were active against species of Enterobacteriaceae other than Citrobacter freundii, Enterobacter aerogenes, and Enterobacter cloacae. Ceftazidime was the most active cephalosporin against Pseudomonas aeruginosa. Against the Enterobacteriaceae, the rank order of activity of penicillins was ticarcillin/clavulanate > piperacillin > mezlocillin > azlocillin. Against P. aer-uginosa, the rank order of activity of penicillins was piperacillin > ticarcillin/clavulanate > azlocillin > mezlocillin. Aztreonam was less active v P. aeruginosa than ceftazidime, cefoperazone, or piperacillin. The most active antimicrobials against all isolates tested were imipenem and ciprofloxacin.

INDEX TERMS
  • Antibiotics
  • Lactam
  • Gram-Negative Bacteria
  • Received March 1988.
  • Accepted September 1988.
  • Copyright © 1989 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine
Vol. 56, Issue 2
1 Mar 1989
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Comparative activity of newer antibiotics against gram-negative bacilli
Cynthia C. Knapp, John A. Washington
Cleveland Clinic Journal of Medicine Mar 1989, 56 (2) 161-166;

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Comparative activity of newer antibiotics against gram-negative bacilli
Cynthia C. Knapp, John A. Washington
Cleveland Clinic Journal of Medicine Mar 1989, 56 (2) 161-166;
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Keywords

  • Antibiotics
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