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Contributions

The usefulness of amiodarone in management of refractory supraventricular tachyarrhythmias

E. Murat Tuzcu, MD, Jennifer Gilbo, BSN, Martin Masterson, MD and James D. Maloney, MD
Cleveland Clinic Journal of Medicine May 1989, 56 (3) 238-242;
E. Murat Tuzcu
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Jennifer Gilbo
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Martin Masterson
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James D. Maloney
Department of Cardiology, The Cleveland Clinic Foundation
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ABSTRACT

The efficacy of amiodarone was evaluated in 85 patients with supraventricular tachycardia (SVT) refractory to several antiarrhythmic agents (mean 3.8 ± 1.0). All but six patients had organic heart disease. Patients were followed for 19 months (range 2 - 60 months). Response to amiodarone treatment was considered excellent (no recurrence of SVT) in 22 of 52 patients with paroxysmal atrial fibrillation (PAF), in four of 13 patients with chronic atrial fibrillation (CAF), and in three of 15 patients with Wolff-Parkin-son-White syndrome-related circus movement tachycardia (WPW - CMT). Response was improved (marked improvement in symptoms with partial suppression of SVT) in 22 patients with PAF, in seven patients with CAF, in 10 patients with WPW-CMT, and in four patients with atrioventricular nodal reentry tachycardia. Response was considered poor (insignificant or no suppression of SVT) in three patients with PAF, in one patient with CAF, and in one patient with WPW-CMT. Seven patients required discontinuation of amiodarone due to adverse effects. We conclude that amiodarone is efficacious and relatively safe for control of SVT refractory to conventional antiarrhythmic agents irrespective of the underlying electrophysiologic mechanism.

INDEX TERMS
  • Amiodarone
  • Arrhythmia
  • Received May 1988.
  • Accepted August 1988.
  • Copyright © 1989 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 56 (3)
Cleveland Clinic Journal of Medicine
Vol. 56, Issue 3
1 May 1989
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The usefulness of amiodarone in management of refractory supraventricular tachyarrhythmias
E. Murat Tuzcu, Jennifer Gilbo, Martin Masterson, James D. Maloney
Cleveland Clinic Journal of Medicine May 1989, 56 (3) 238-242;

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The usefulness of amiodarone in management of refractory supraventricular tachyarrhythmias
E. Murat Tuzcu, Jennifer Gilbo, Martin Masterson, James D. Maloney
Cleveland Clinic Journal of Medicine May 1989, 56 (3) 238-242;
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  • ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines and Policy Conferences (Committee to Develop Guidelines for the Management of Patients With Atrial Fibrillation) Developed in Collaboration With the North American Society of Pacing and Electrophysiology
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Keywords

  • Amiodarone
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