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Contributions

The ANA Profile: quality and cost-effective laboratory utilization

John D. Clough, MD, Leonard H. Calabrese, DO and Rafael Valenzuela, MD
Cleveland Clinic Journal of Medicine May 1989, 56 (3) 245-248;
John D. Clough
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Leonard H. Calabrese
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Rafael Valenzuela
Department of Immunopathology, The Cleveland Clinic Foundation
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ABSTRACT

The ANA Profile was introduced in 1981 and computerized in 1984 as a means of facilitating follow-up testing for specific antibodies (anti-nDNA, anti-Sm, anti-RNP, anti-La/SS-B) in sera found to contain antinuclear antibodies (ANA). A second purpose was to avoid unnecessary specific antibody testing on negative or low-titer sera. This study was done to evaluate the effectiveness of the computerized ANA Profile reporting system in accomplishing these purposes. The authors compared ordering practices during two two-week periods, one in 1984 and a second in 1988, and found that follow-up testing on positive sera had improved from 27 % to 70 % with a reduction in unnecessary specific-antibody testing of ANA-negative or low-titer sera from 11% to 1.6%. In 1988 dollars, the annual savings from eliminating unnecessary testing was calculated to be $12,000. The ANA Profile has been partially successful in accomplishing the purposes for which it was introduced.

INDEX TERM
  • Antinuclear Factors
  • Received May 1988.
  • Accepted August 1988.
  • Copyright © 1989 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 56 (3)
Cleveland Clinic Journal of Medicine
Vol. 56, Issue 3
1 May 1989
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The ANA Profile: quality and cost-effective laboratory utilization
John D. Clough, Leonard H. Calabrese, Rafael Valenzuela
Cleveland Clinic Journal of Medicine May 1989, 56 (3) 245-248;

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The ANA Profile: quality and cost-effective laboratory utilization
John D. Clough, Leonard H. Calabrese, Rafael Valenzuela
Cleveland Clinic Journal of Medicine May 1989, 56 (3) 245-248;
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