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VanOrdstrand Festschrift

Immune mechanisms in beryllium lung disease

Sharad D. Deodhar, MD, PhD and Barbara P. Barna, PhD
Cleveland Clinic Journal of Medicine March 1991, 58 (2) 157-160;
Sharad D. Deodhar
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Barbara P. Barna
Department of Immunopathology, The Cleveland Clinic Foundation.
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ABSTRACT

The role of the immune system in the pathogenesis of beryllium lung disease has been suspected for years. The observation of cutaneous hypersensitivity to beryllium led to the development of the lymphocyte blast transformation test; the test clearly distinguishes between healthy subjects, who show little or no blast transformation response, and patients with beryllium lung disease, who demonstrate significant responses. The degree of blast transformation also correlates with the severity of the clinical disease. Animal studies have demonstrated the importance of histocompatibility antigens in development of the disease, and support the participation of cellular immune mechanisms.

INDEX TERMS
  • Beryllium Lung Disease
  • Copyright © 1991 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 58 (2)
Cleveland Clinic Journal of Medicine
Vol. 58, Issue 2
1 Mar 1991
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Immune mechanisms in beryllium lung disease
Sharad D. Deodhar, Barbara P. Barna
Cleveland Clinic Journal of Medicine Mar 1991, 58 (2) 157-160;

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Immune mechanisms in beryllium lung disease
Sharad D. Deodhar, Barbara P. Barna
Cleveland Clinic Journal of Medicine Mar 1991, 58 (2) 157-160;
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