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Clinical Reviews

Colorectal cancer in ulcerative colitis patients: survival curves and surveillance

Bret A. Lashner, MD
Cleveland Clinic Journal of Medicine July 1994, 61 (4) 272-275;
Bret A. Lashner
Center for Inflammatory Bowel Disease, the Department of Gastroenterology, The Cleveland Clinic Foundation.
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ABSTRACT

BACKGROUND Survival curves can provide useful information for designing cancer surveillance programs.

OBJECTIVE To outline how to derive the density and hazard functions from the survival curve and to use this information to make recommendations regarding cancer surveillance in patients with ulcerative colitis.

DISCUSSION The hazard of cancer or dysplasia remains low during the first decade of ulcerative colitis but rises exponentially thereafter. After 40 years, approximately 20% of patients with ulcerative colitis acquire cancer or dysplasia per year.

CONCLUSION A reasonable recommendation for cancer surveillance based on information from survival curves would be a colonoscopy with biopsy approximately 10 years after the onset of ulcerative colitis, and repeated every 3 years for the next decade, every 2 years for the subsequent decade, and every year thereafter. Prophylactic proctocolectomy is an option after 40 years of disease due to the extremely high cancer risk, but data supporting this option are sparse.

INDEX TERMS
  • COLORECTAL NEOPLASMS
  • COLITIS
  • ULCERATIVE
  • SURVIVAL ANALYSIS
  • Copyright © 1994 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 61 (4)
Cleveland Clinic Journal of Medicine
Vol. 61, Issue 4
1 Jul 1994
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Colorectal cancer in ulcerative colitis patients: survival curves and surveillance
Bret A. Lashner
Cleveland Clinic Journal of Medicine Jul 1994, 61 (4) 272-275;

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Colorectal cancer in ulcerative colitis patients: survival curves and surveillance
Bret A. Lashner
Cleveland Clinic Journal of Medicine Jul 1994, 61 (4) 272-275;
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Keywords

  • COLORECTAL NEOPLASMS
  • COLITIS
  • ULCERATIVE
  • SURVIVAL ANALYSIS

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