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Review

Nephrogenic systemic fibrosis and its association with gadolinium exposure during MRI

Naim Issa, MD, Emilio D. Poggio, MD, Richard A. Fatica, MD, Rajiv Patel, MD, Paul M. Ruggieri, MD and Robert J. Heyka, MD
Cleveland Clinic Journal of Medicine February 2008, 75 (2) 95-111;
Naim Issa
Department of Nephrology and Hypertension, Cleveland Clinic
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Emilio D. Poggio
Director of Renal Function Laboratory, Department of Nephrology and Hypertension, Cleveland Clinic
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Richard A. Fatica
Nephrology Fellowship Program Director, Department of Nephrology and Hypertension, Cleveland Clinic
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Rajiv Patel
Department of Dermatopathology, Cleveland Clinic
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Paul M. Ruggieri
Head, Section of Magnetic Resonance, Department of Diagnostic Radiology, Cleveland Clinic
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Robert J. Heyka
Director of Chronic Hemodialysis, Department of Nephrology and Hypertension, Cleveland Clinic
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ABSTRACT

Nephrogenic systemic fibrosis (NSF) is a newly recognized systemic disorder characterized by widespread tissue fibrosis in patients with impaired renal function. Recent reports suggest that NSF is associated with exposure to gadolinium-based contrast agents used in magnetic resonance imaging. NSF can be very debilitating and can lead to serious complications and death. Health care providers should exercise caution when considering the use of gadolinium-based imaging studies in patients with renal dysfunction.

  • Copyright © 2008 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 75 (2)
Cleveland Clinic Journal of Medicine
Vol. 75, Issue 2
1 Feb 2008
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Nephrogenic systemic fibrosis and its association with gadolinium exposure during MRI
Naim Issa, Emilio D. Poggio, Richard A. Fatica, Rajiv Patel, Paul M. Ruggieri, Robert J. Heyka
Cleveland Clinic Journal of Medicine Feb 2008, 75 (2) 95-111;

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Nephrogenic systemic fibrosis and its association with gadolinium exposure during MRI
Naim Issa, Emilio D. Poggio, Richard A. Fatica, Rajiv Patel, Paul M. Ruggieri, Robert J. Heyka
Cleveland Clinic Journal of Medicine Feb 2008, 75 (2) 95-111;
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