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Session V: Insights into Neuromodulation of Cardiovascular Function

Pinacidil induces vascular dilation and hyperemia in vivo and does not impact biophysical properties of neurons and astrocytes in vitro

Rosa Cao, Bryan T. Higashikubo, Jessica Cardin, Ulf Knoblich, Raddy Ramos, PhD, Mark T. Nelson, PhD, Christopher I. Moore, PhD and Joshua C. Brumberg, PhD
Cleveland Clinic Journal of Medicine February 2009, 76 (4 suppl 2) S80-S85; DOI: https://doi.org/10.3949/ccjm.76.s2.16
Rosa Cao
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA
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Bryan T. Higashikubo
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA
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Jessica Cardin
McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA
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Ulf Knoblich
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA
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Raddy Ramos
Department of Neuroscience & Histology, New York College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY
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Mark T. Nelson
Department of Pharmacology, College of Medicine, University of Vermont, Burlington
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Christopher I. Moore
McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA
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  • For correspondence: [email protected]
Joshua C. Brumberg
Department of Psychology, Queens College and The Graduate Center, CUNY, Flushing, NY
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  • For correspondence: [email protected]
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ABSTRACT

Vascular and neural systems are highly interdependent, as evidenced by the wealth of intrinsic modulators shared by the two systems. We tested the hypothesis that pinacidil, a selective agonist for the SUR2B receptor found on smooth muscles, could serve as an independent means of inducing vasodilation and increased local blood volume to emulate functional hyperemia. Application of pinacidil induced vasodilation and increased blood volume in the in vivo neocortex in anesthetized rats and awake mice. Direct application of this agent to the in vitro neocortical slice had no direct impact on biophysical properties of neurons or astrocytes assessed with whole-cell recording. These findings suggest that pinacidil provides an effective and selective means for inducing hyperemia in vivo, and may provide a useful tool in directly testing the impact of hemodynamics on neural activity, as recently predicted by the hemo-neural hypothesis.

  • © 2009 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 76 (4 suppl 2)
Cleveland Clinic Journal of Medicine
Vol. 76, Issue 4 suppl 2
1 Feb 2009
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Pinacidil induces vascular dilation and hyperemia in vivo and does not impact biophysical properties of neurons and astrocytes in vitro
Rosa Cao, Bryan T. Higashikubo, Jessica Cardin, Ulf Knoblich, Raddy Ramos, Mark T. Nelson, Christopher I. Moore, Joshua C. Brumberg
Cleveland Clinic Journal of Medicine Feb 2009, 76 (4 suppl 2) S80-S85; DOI: 10.3949/ccjm.76.s2.16

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Pinacidil induces vascular dilation and hyperemia in vivo and does not impact biophysical properties of neurons and astrocytes in vitro
Rosa Cao, Bryan T. Higashikubo, Jessica Cardin, Ulf Knoblich, Raddy Ramos, Mark T. Nelson, Christopher I. Moore, Joshua C. Brumberg
Cleveland Clinic Journal of Medicine Feb 2009, 76 (4 suppl 2) S80-S85; DOI: 10.3949/ccjm.76.s2.16
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