Putting genome analysis to good use: Lessons from C-reactive protein and cardiovascular disease

Leslie Cole Manace, MD, MPhil
Leslie Cole Manace
Department of Genetics, Kaiser Permanente Oakland Medical Center, and Assistant Professor, Department of Medicine, University of California, San Francisco
MD, MPhil
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- For correspondence: [email protected]
and Mark Warren Babyatsky, MD
Mark Warren Babyatsky
Chairman, Samuel Bronfman Department of Medicine, and Drs. Richard and Mortimer Bader Professor of Medicine, Mount Sinai School of Medicine, New York, NY
MD

Cleveland Clinic Journal of Medicine
March 2012,
79
(3)
182-191;
DOI: https://doi.org/10.3949/ccjm.79a.09169

ABSTRACT

New methods of studying the human genome offer novel ways to examine the relationship between biomarkers and common, chronic human diseases. As an example, we will review a large genomics study (Elliott et al, JAMA 2009; 302:37–48) that concluded that C-reactive protein (CRP) is likely not a cause of coronary heart disease, although it is a marker for it.

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Putting genome analysis to good use: Lessons from C-reactive protein and cardiovascular disease

Leslie Cole Manace

Leslie Cole Manace

and Mark Warren Babyatsky

Mark Warren Babyatsky

Cleveland Clinic Journal of Medicine

March 2012,

79

(3)

182-191;

DOI: 10.3949/ccjm.79a.09169

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Putting genome analysis to good use: Lessons from C-reactive protein and cardiovascular disease

Leslie Cole Manace

Leslie Cole Manace

and Mark Warren Babyatsky

Mark Warren Babyatsky

Cleveland Clinic Journal of Medicine

March 2012,

79

(3)

182-191;

DOI: 10.3949/ccjm.79a.09169

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