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Current Drug Therapy

Protease inhibitors: Silver bullets for chronic hepatitis C infection?

Naim Alkhouri, MD and Nizar N. Zein, MD
Cleveland Clinic Journal of Medicine March 2012, 79 (3) 213-222; DOI: https://doi.org/10.3949/ccjm.79a.11082
Naim Alkhouri
Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH
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Nizar N. Zein
Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH
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ABSTRACT

Recent trials evaluated the safety and efficacy of two protease inhibitors, boceprevir (Victrelis) and telaprevir (Incivek), added to standard care with pegylated interferon and ribavirin, in patients with chronic hepatitis C virus (HCV) infection. These drugs open the door for triple therapy and other new therapies involving combinations of other direct-acting antiviral agents to become the new standard of care for this population.

Footnotes

  • ↵* Dr. Zein has disclosed consulting, teaching, speaking, and receiving research funding from Merck (makers of boceprevir) and Vertex (makers of telaprevir).

  • Copyright © 2012 The Cleveland Clinic Foundation. All Rights Reserved.

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Cleveland Clinic Journal of Medicine: 79 (3)
Cleveland Clinic Journal of Medicine
Vol. 79, Issue 3
1 Mar 2012
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Protease inhibitors: Silver bullets for chronic hepatitis C infection?
Naim Alkhouri, Nizar N. Zein
Cleveland Clinic Journal of Medicine Mar 2012, 79 (3) 213-222; DOI: 10.3949/ccjm.79a.11082

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Protease inhibitors: Silver bullets for chronic hepatitis C infection?
Naim Alkhouri, Nizar N. Zein
Cleveland Clinic Journal of Medicine Mar 2012, 79 (3) 213-222; DOI: 10.3949/ccjm.79a.11082
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