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Review

The role of aldosterone receptor antagonists in the management of heart failure: An update

Vijaiganesh Nagarajan, MD, Mohammed Chamsi-Pasha, MD and W. H. Wilson Tang, MD
Cleveland Clinic Journal of Medicine September 2012, 79 (9) 631-639; DOI: https://doi.org/10.3949/ccjm.79a.12014
Vijaiganesh Nagarajan
Department of Hospital Medicine, Cleveland Clinic
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Mohammed Chamsi-Pasha
Department of Internal Medicine, Cleveland Clinic
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W. H. Wilson Tang
Director of Cardiomyopathy Program and Research Director, Section of Heart Failure and Cardiac Transplantation Medicine, Cleveland Clinic; Associate Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
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ABSTRACT

The aldosterone receptor antagonists (ARAs) spironolactone (Aldactone) and eplerenone (Inspra) have become part of standard medical therapy for heart failure, having shown clinical efficacy in randomized trials in patients with advanced symptomatic systolic heart failure, postinfarction heart failure with cardiac dysfunction, and systolic heart failure with mild symptoms. The benefits include a lower rate of death. Yet to be answered is whether the two drugs are clinically equivalent; another question is whether they may benefit everyone with symptomatic heart failure, including diastolic heart failure.

  • Copyright © 2012 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 79 (9)
Cleveland Clinic Journal of Medicine
Vol. 79, Issue 9
1 Sep 2012
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The role of aldosterone receptor antagonists in the management of heart failure: An update
Vijaiganesh Nagarajan, Mohammed Chamsi-Pasha, W. H. Wilson Tang
Cleveland Clinic Journal of Medicine Sep 2012, 79 (9) 631-639; DOI: 10.3949/ccjm.79a.12014

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The role of aldosterone receptor antagonists in the management of heart failure: An update
Vijaiganesh Nagarajan, Mohammed Chamsi-Pasha, W. H. Wilson Tang
Cleveland Clinic Journal of Medicine Sep 2012, 79 (9) 631-639; DOI: 10.3949/ccjm.79a.12014
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