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Addressing Disparities in Healthcare

Genitourinary manifestations of sickle cell disease

Surafel Gebreselassie, MD, Matthew N. Simmons, MD, PhD and Drogo K. Montague, MD
Cleveland Clinic Journal of Medicine October 2015, 82 (10) 679-683; DOI: https://doi.org/10.3949/ccjm.82a.14029
Surafel Gebreselassie
Transplant Center, Cleveland Clinic Florida, Weston; Assistant Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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Matthew N. Simmons
Urology Specialists of Oregon, Bend, OR
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Drogo K. Montague
Center for Genitourinary Reconstruction, Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic; Professor of Surgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH; former Chair, American Urological Association Erectile Dysfunction Guideline Update Panel
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ABSTRACT

Sickle cell disease is a common genetic disorder characterized by sickling of red blood cells under conditions of reduced oxygen tension. In turn, sickling leads to intravascular hemolysis and vaso-occlusive events with subsequent tissue ischemia-reperfusion injury affecting multiple organs, including the genitourinary system. Our review of the genitourinary manifestations of sickle cell disease focuses on sickle cell nephropathy, priapism, and other genitourinary complications such as papillary necrosis and renal medullary carcinoma.

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Cleveland Clinic Journal of Medicine: 82 (10)
Cleveland Clinic Journal of Medicine
Vol. 82, Issue 10
1 Oct 2015
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Genitourinary manifestations of sickle cell disease
Surafel Gebreselassie, Matthew N. Simmons, Drogo K. Montague
Cleveland Clinic Journal of Medicine Oct 2015, 82 (10) 679-683; DOI: 10.3949/ccjm.82a.14029

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Genitourinary manifestations of sickle cell disease
Surafel Gebreselassie, Matthew N. Simmons, Drogo K. Montague
Cleveland Clinic Journal of Medicine Oct 2015, 82 (10) 679-683; DOI: 10.3949/ccjm.82a.14029
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