ABSTRACT
This review focuses an alternative strategy utilizing small molecules to inhibit a key signal-transduction pathway, the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway. The JAK-STAT pathway mediates biologic activity for a large number of inflammatory cytokines and mediators.
- Copyright © 2020 The Cleveland Clinic Foundation. All Rights Reserved.
- Leonard H. Calabrese, DO⇑
- Department of Rheumatic and Immunologic Diseases, Orthopedic & Rheumatologic Institute, Cleveland Clinic
- Correspondence:
Leonard H. Calabrese, DO, Department of Rheumatic and Immunologic Diseases, A50, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; calabrl{at}ccf.org
- Tiphaine Lenfant, MD
- Cassandra Calabrese, DO
ABSTRACT
This review focuses an alternative strategy utilizing small molecules to inhibit a key signal-transduction pathway, the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway. The JAK-STAT pathway mediates biologic activity for a large number of inflammatory cytokines and mediators.
- Copyright © 2020 The Cleveland Clinic Foundation. All Rights Reserved.