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Current Drug Therapy

Calcium-channel antagonists: mechanisms of action, vascular selectivities, and clinical relevance

Alan Bakst, PharmD and David J. Triggle, PhD
Cleveland Clinic Journal of Medicine November 1992, 59 (6) 617-627;
Donald G. Vidt
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Alan Bakst
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David J. Triggle
School of Pharmacy, State University of New York, Buffalo.
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ABSTRACT

The calcium-channel antagonists represent three separate structural categories of drugs. They share a common action—the blockade of calcium-ion flow through one specific type of calcium channel. The chemical heterogeneity of these agents is reflected in their pharmacologic and therapeutic diversity. The calcium-channel antagonists enjoy significant use in cardiovascular medicine for the treatment of hypertension, angina, and some cardiac arrhythmias. However, the 1,4-dihydropyridines, the most potent antihypertensive calcium-channel blockers, lack antiarrhythmic properties. The selectivity of action of calcium-channel antagonists rests upon a number of factors, including pathways of calcium mobilization, types of channel activated, state-dependent interactions, and the pathological state of the tissue. A n understanding of these factors is important to the rational application of these drugs and to the development of newer agents with different specificities.

INDEX TERMS
  • Calcium-Channel Blockers
  • Calcium Channels
  • Cardiovascular Diseases
  • Copyright © 1992 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 59 (6)
Cleveland Clinic Journal of Medicine
Vol. 59, Issue 6
1 Nov 1992
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Calcium-channel antagonists: mechanisms of action, vascular selectivities, and clinical relevance
Alan Bakst, David J. Triggle
Cleveland Clinic Journal of Medicine Nov 1992, 59 (6) 617-627;

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Calcium-channel antagonists: mechanisms of action, vascular selectivities, and clinical relevance
Alan Bakst, David J. Triggle
Cleveland Clinic Journal of Medicine Nov 1992, 59 (6) 617-627;
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Keywords

  • Calcium-Channel Blockers
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