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Selected Papers in Dermatology

Long-term and short-term histopathologic changes in the skin after PU VA therapy

Daniel M. Ingraham, D.O., Wilma F. Bergfeld, M.D., Philip L. Bailin, M.D., Willard D. Steck, M.D., James S. Taylor, M.D. and Kenneth J. Tomecki, M.D.
Cleveland Clinic Journal of Medicine June 1983, 50 (2) 133-139;
Daniel M. Ingraham
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Wilma F. Bergfeld
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Philip L. Bailin
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Willard D. Steck
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James S. Taylor
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Kenneth J. Tomecki
Department of Dermatology, The Cleveland Clinic Foundation
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ABSTRACT

Psoriatic patients engaged in chronic psoralen and long-wave ultraviolet light therapy (PUVA) were evaluated for temporary and permanent histologic changes of the skin. Biopsies of skin from the buttock were taken before, during, and three years after PUVA therapy and histologic changes were compared. Hyperkeratosis, acanthosis, melanosis, and occasional focal dysplasia were noted in the epidermis. Increased deposition of acid mucopolysaccharide (hyaluronic acid), decreased, fragmented elastic fibers within the papillary dermis, and increased, thickened elastic fibers within the reticular dermis were observed. Comparison between changes seen after long-term continuous PUVA therapy and those seen three years later showed no significant differences, indicating that these changes may be irreversible.

Index terms
  • Psoriasis
  • therapy
  • PUVA
  • Skin
  • diseases
  • Received February 1983.
  • Accepted March 1983.
  • Copyright © 1983 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 50 (2)
Cleveland Clinic Journal of Medicine
Vol. 50, Issue 2
20 Jun 1983
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Long-term and short-term histopathologic changes in the skin after PU VA therapy
Daniel M. Ingraham, Wilma F. Bergfeld, Philip L. Bailin, Willard D. Steck, James S. Taylor, Kenneth J. Tomecki
Cleveland Clinic Journal of Medicine Jun 1983, 50 (2) 133-139;

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Long-term and short-term histopathologic changes in the skin after PU VA therapy
Daniel M. Ingraham, Wilma F. Bergfeld, Philip L. Bailin, Willard D. Steck, James S. Taylor, Kenneth J. Tomecki
Cleveland Clinic Journal of Medicine Jun 1983, 50 (2) 133-139;
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Keywords

  • Psoriasis
  • therapy
  • PUVA
  • Skin
  • diseases

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