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Selected Papers in Dermatology

Hyaluronic acid synthesis in fibroblasts of prétibial myxedema

C. William Hanke, M.D., Wilma F. Bergfeld, M.D., Marcelle N. Guirguis, M.D. and L. James Lewis, Ph.D.
Cleveland Clinic Journal of Medicine June 1983, 50 (2) 129-132;
C. William Hanke
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Wilma F. Bergfeld
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Marcelle N. Guirguis
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L. James Lewis
Department of Dermatology, The Cleveland Clinic Foundation.
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ABSTRACT

Hyaluronic acid production by fibroblasts from skin lesions of prétibial myxedema (PTM) and also from normal control skin was studied in tissue culture. Normal control fibroblasts produced increased amounts of hyaluronic acid when serum from patients with PTM was used to supplement the tissue culture medium. Further increases in hyaluronic acid synthesis were noted when PTM fibroblasts were incubated with normal human serum, and when PTM fibroblasts were incubated with serum from patients with PTM. These results suggest that a serum factor is operative in patients with PTM, and that this serum factor can influence the production of hyaluronic acid in both normal controls and PTM fibroblasts. This increased production of hyaluronic acid by fibro-blasts may be a major factor in the pathogenesis of PTM.

Index terms
  • Hyaluronic acid
  • Skin
  • diseases
  • Received March 1983.
  • Accepted April 1983.
  • Copyright © 1983 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 50 (2)
Cleveland Clinic Journal of Medicine
Vol. 50, Issue 2
20 Jun 1983
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Hyaluronic acid synthesis in fibroblasts of prétibial myxedema
C. William Hanke, Wilma F. Bergfeld, Marcelle N. Guirguis, L. James Lewis
Cleveland Clinic Journal of Medicine Jun 1983, 50 (2) 129-132;

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Hyaluronic acid synthesis in fibroblasts of prétibial myxedema
C. William Hanke, Wilma F. Bergfeld, Marcelle N. Guirguis, L. James Lewis
Cleveland Clinic Journal of Medicine Jun 1983, 50 (2) 129-132;
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