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I. Epilepsy: Current Concepts in Diagnosis and Treatment

Infantile spasms

Robert P. Cruse, D.O.
Cleveland Clinic Journal of Medicine June 1984, 51 (2) 273-278;
Robert P. Cruse
Department of Neurology and the Department of Pediatrics and Adolescent Medicine, The Cleveland Clinic Foundation
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ABSTRACT

West's syndrome is an age-specific set of symptoms consisting of myoclonic epilepsy (infantile spasms), an interictal electroencephalographic pattern (hypsarrhythmia), and moderate-to-severe mental retardation. Infantile spasms were first reported in 1841, but all three characteristics were not described until 1951. The basic pathophysiology of and ideal therapy for the seizures remain undefined. The author reviews the historical aspects, clinical manifestations, etiology, diagnostic evaluation, and treatment of West's syndrome.

Index terms
  • Epilepsy
  • myoclonus
  • Mental retardation
  • Spasms
  • infantile
  • Received October 1983.
  • Accepted October 1983.
  • Copyright © 1984 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 51 (2)
Cleveland Clinic Journal of Medicine
Vol. 51, Issue 2
20 Jun 1984
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Infantile spasms
Robert P. Cruse
Cleveland Clinic Journal of Medicine Jun 1984, 51 (2) 273-278;

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Robert P. Cruse
Cleveland Clinic Journal of Medicine Jun 1984, 51 (2) 273-278;
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More in this TOC Section

I. Epilepsy: Current Concepts in Diagnosis and Treatment

  • Diagnosis and treatment of absence seizures
  • Corpus callosum section for seizure control: rationale and review of experimental and clinical data
  • Review of the 20-year UCLA experience with surgery for epilepsy
Show more I. Epilepsy: Current Concepts in Diagnosis and Treatment

Contributions

  • Diagnosis and treatment of absence seizures
  • Corpus callosum section for seizure control: rationale and review of experimental and clinical data
  • Review of the 20-year UCLA experience with surgery for epilepsy
Show more Contributions

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Keywords

  • Epilepsy
  • myoclonus
  • Mental retardation
  • Spasms
  • infantile

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